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Visual Perceptual Learning for the Treatment of Visual Field Defect — VIVID  

Stroke Clinical Trial

Official title:
Visual Perceptual Learning for the Treatment of Visual Field Defect

Clinical Trial Summary

This study will test the hypothesis whether visual field defect caused by chronic stroke could be improved by visual perceptual learning. The secondary hypothesis is that improvement of visual field defect would be accompanied by connectivity changes in visual networks. In addition, investigators will evaluate whether improvement of visual field defect could achieve improvement of subjective visual function.

Clinical Trial Description

Study design: A PROBE (Prospective, Randomized, Open-label, Blinded-endpoint) design

Methods:

1. Visual perceptual learning (VPL) group

1. Visual perceptual learning (24 times for 2 months, 3 times per week) in visual field defect areas

2. At baseline and post-VPL evaluations (2 months after): Structural & Functional MRIs, Visual field tests, Visual evoked potential, Visual cognitive tests, Subjective visual function questionnaires

2. Control group

1. At baseline and 2-months later: No VPL, Structural & Functional MRIs, Visual field tests, Visual evoked potential, Visual cognitive tests, Subjective visual function questionnaires

2. Visual perceptual learning after 2-month follow-up evaluation (24 times for 2 months, 3 times per week)

(The patients who were stratified by age (over 65 years old or not) and degree of visual field defect (quadrantanopia or complete hemianopia) will be randomly assigned into the learning and control group.)

3. Investigations

1. Improvement of visual field test scores between VPL group and control group

2. Analysis of brain network changes in MRI data

3. Correlation analysis of improvement of visual field defect and MRI data

4. Correlation analysis of improvement of visual field defect and visual evoked potential (VEP) data

5. Correlation analysis of improvement of visual field defect and neuropsychological data ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01959256
Study type Interventional
Source Asan Medical Center
Contact
Status Completed
Phase N/A
Start date October 2013
Completion date January 2018
View Details
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