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NCT01152944 Clinical Trial

Mechanisms of Stroke in Intracranial Stenosis

Stroke Clinical Trial

— MoSIS  

Official title:
Mechanisms of Stroke in Intracranial Stenosis and Stenting

Clinical Trial Details — Status: Terminated

Administrative data
NCT number NCT01152944
Other study ID # 1R01NS069938-01
Secondary ID 1R01NS069938-01
Status Terminated
Phase N/A
First received June 28, 2010
Last updated February 6, 2012
Start date July 2010
Est. completion date December 2011

Study information
Verified date February 2012
Source University of Miami
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Observational

Clinical Trial Summary

The objective of this SAMMPRIS-affiliated study is to understand the mechanisms the mechanisms that underlie ischemic stroke recurrence in high-grade intracranial atherosclerotic disease in order to determine predictors of recurrent stroke. MoSIS will evaluate 6 specific mechanisms of stroke in the medically-treated SAMMPRIS cohort: decreased antegrade flow, progression of stenosis, decreased proximal collateral flow, decreased distal collateral flow, impaired cerebrovascular reserve, and artery-to-artery embolism.

Recruitment information / eligibility
Status Terminated
Enrollment 100
Est. completion date December 2011
Est. primary completion date April 2011
Accepts healthy volunteers No
Gender Both
Age group 30 Years to 80 Years
Eligibility Inclusion Criteria:

- Enrolled in the medical arm of SAMMPRIS, signed consent

Exclusion Criteria:

- For QMRA testing: contraindications to MRI; for TCD testing, abscence of ultrasonographic windows.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
United States University of Miami Miami Florida

Sponsors (2)
Lead Sponsor Collaborator
Jose Romano, MD National Institute of Neurological Disorders and Stroke (NINDS)

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Ischemic stroke in the territory of the stenotic artery 2 years from enrollment No
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