Acute Stroke Program of Interventions Addressing Racial and Ethnic Disparities

Stroke Clinical Trial

— ASPIRE  

Official title:

Acute Stroke Program of Interventions Addressing Racial and Ethnic Disparities

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00724555
• Other study ID #: U54NS057405_ASPIRE
• Secondary ID: 2007-439
• Status: Completed
• Phase: N/A
• First received: July 28, 2008
• Last updated: January 30, 2014
• Start date: February 2008
• Est. completion date: January 2013

Study information

• Verified date: January 2014
• Source: Georgetown University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal GovernmentUnited States: Georgetown University Institutional Review Board
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to increase treatment of acute stroke with tissue plasminogen activator (tPA) across the District of Columbia. This study, however, will not evaluate tPA as an intervention.

Description:

There are a number of well-known barriers to receiving tissue plasminogen activator (tPA) including transit time to hospital, paramedic and provider training, tPA standing orders, and provider guidelines. Among underserved populations, limited stroke knowledge, socioculturally determined attitudes, and beliefs and myths held by community members may serve as additional barriers that hinder these populations from receiving tPA and acute stroke care. Targeted multilevel interventions designed to overcome specific barriers may significantly increase the number of individuals with stroke who are appropriately treated with intravenous tPA (IV tPA) in underserved communities. Identification of the specific components of healthcare interventions that are the most effective is critical to improve delivery of acute stroke therapy.

The goal of this study is to learn more about public knowledge, attitudes, beliefs and perceptions regarding stroke and stroke treatment in order to identify sociocultural and environmental barriers to receiving tPA and acute stroke care in an underserved community. This study will also determine if implementation of a multilevel intervention program can significantly increase the number of people with ischemic stroke who are appropriately treated with IV tPA in a predominantly underserved community.

In the study, researchers will evaluate the different levels of the intervention to determine which efforts are most effective.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 2005
• Est. completion date: January 2013
• Est. primary completion date: January 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• diagnosis of acute ischemic stroke

• over the age of 18

Exclusion Criteria:

Study Design

Observational Model: Ecologic or Community, Time Perspective: Prospective

Related Conditions & MeSH terms

• Stroke

Locations

Country	Name	City	State
United States	Columbia University Medical Center	New York	New York
United States	George Washington University Hospital	Washington	District of Columbia
United States	Georgetown University, ASPIRE Coordinating Center	Washington	District of Columbia
United States	Howard University Hospital	Washington	District of Columbia
United States	Providence Hospital	Washington	District of Columbia
United States	Sibley Memorial Hospital	Washington	District of Columbia
United States	United Medical Center (formerly known as Greater Southeast Community Hospital)	Washington	District of Columbia
United States	Washington Hospital Center	Washington	District of Columbia

Sponsors (11)

Lead Sponsor	Collaborator
Georgetown University	George Washington University, Howard University, Johns Hopkins University, MedStar Good Samaritan Hospital, Medstar Research Institute, Union Memorial Hospital, University of Alabama at Birmingham, University of Michigan, University of Wisconsin, Madison, Washington Hospital Center

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The proportion of people with ischemic stroke appropriately treated with IV tPA.		4 years	No
Secondary	Qualitative data collected from the community will identify baseline levels of knowledge, attitudes, and perceived and encountered barriers to acute stroke treatment.		1 year	No