Stroke Clinical Trial
Official title:
The Role of Cerebral Hemodynamics in Moyamoya Disease
The purpose of this study is to determine if people with moyamoya disease who have insufficient blood flow are at a higher risk for stroke.
Moyamoya disease is a rare medical disorder that affects the blood vessels (pipes that
transport blood) in the brain. In Moyamoya disease, the large blood vessels in the middle of
the brain close down over time. The cause of this disorder is unknown. In order to compensate
for this narrowing, the body grows new small blood vessels around the blockage. These small
branches grow larger (and may be more numerous) to give the disorder its name. "Moyamoya" is
the Japanese term for "puff of smoke" and is used to describe the hazy appearance of these
small blood vessels on an angiogram.
Treatment for moyamoya is difficult because so little is known about the disease. Some people
never have a stroke while others may have several. It is likely that the strokes are due to
insufficient blood flow to the brain. There are surgical procedures that may improve blood
flow to the brain, however, these procedures may cause complications and may not always
improve the blood flow.
The main purpose of this study is to determine if people with moyamoya disease who have
insufficient blood flow are at a higher risk for stroke. In this study researchers will learn
more about the risks and potential benefits of surgical treatment. This information will help
decide if there are people at higher risk for stroke who might benefit from surgery or if
there are those at a lower risk who might not benefit.
In this study, participants will undergo baseline clinical and laboratory evaluation.
Measurements of blood flow to the brain and oxygen use will be obtained using by positron
emission tomography (PET). Participants will be followed for up to 5 years. PET studies will
be conducted one and three years after enrollment to determine if blood flow improves over
time. Participants treated with surgery (at the discretion of their treating physicians) will
also be followed for perioperative complications, improvement in blood flow, and long term
risk of stroke.
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