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NCT00530478 Clinical Trial

Effect of Donepezil on the Reorganization of Cognitive Neural Network in Patients With Post-Stroke Cognitive Impairment

Stroke Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00530478
Other study ID # 2006-04-023
Secondary ID
Status Recruiting
Phase N/A
First received September 13, 2007
Last updated September 13, 2007

Study information
Verified date July 2007
Source Samsung Medical Center
Contact Yun-Hee Kim, MD, PHD
Phone 82-2-3410-2818
Email yunkim@smc.samsung.co.kr
Is FDA regulated No
Health authority South Korea: Institutional Review BoardSouth Korea: Korea Food and Drug Administration (KFDA)
Study type Interventional

Clinical Trial Summary

The purpose of this study is to demonstrate the efficacy and safety of donepezil on the recovery of cognitive function in patients with stroke and to delineate the neurophysiologic mechanisms of the therapeutic effect of donepezil on the recovery of cognitive network using functional neuroimaging technique.

Recruitment information / eligibility
Status Recruiting
Enrollment 0
Est. completion date
Est. primary completion date
Accepts healthy volunteers
Gender Both
Age group 16 Years to 80 Years
Eligibility Inclusion Criteria:

- Ischemic stroke in the territory of right or left middle cerebral artery

- Post-onset duration of the recent-onset stroke is over 3 months

- Cognitive deficit ranged from 10 to 26 by minimal mental status examination (MMSE) score

- Disturbance in activities of daily living (ADL) ranged 0.5 ~ 2.0 by clinical dementia rating (CDR) scale

Exclusion Criteria:

- Severe internal carotid artery stenosis on the lesion side

- Cardiac pacemaker or intracranial metal insertion

- Post-stroke seizure disorder or any evidence of epileptic spikes on electroencephalography (EEG)

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label

Related Conditions & MeSH terms

Intervention

Drug:
• Donepezil

Locations
Country Name City State
Korea, Republic of Samsung Medical Center Seoul

Sponsors (1)
Lead Sponsor Collaborator
Samsung Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

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