Neural Correlates of Lower Extremity Motor Recovery in Stroke Patients: Longitudinal Diffusion Spectrum Imaging Studies

Stroke Clinical Trial

Official title:

Neural Correlates of Lower Extremity Motor Recovery in Stroke Patients: Longitudinal Diffusion Spectrum Imaging Studies

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00407628
• Other study ID #: 9561703031
• Secondary ID: NSC95-2314-B-002
• Status: Completed
• Phase: N/A
• First received: December 3, 2006
• Last updated: July 4, 2013
• Start date: August 2006
• Est. completion date: July 2009

Study information

• Verified date: January 2013
• Source: National Taiwan University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Taiwan: Department of Health
• Study type: Observational

Clinical Trial Summary

To investigate the relationship between the integrity of the white matter, including the corticospinal tracts and the corpus callosum, with the recovery of lower extremity function in patients with cerebral stroke at the subacute and chronic stages.

Description:

Recent studies have provided strong evidence that motor recovery after adult ischemic stroke is a function of neural plasticity. Up to date, it remains largely unknown as to the relationship between the integrity of the subcortical white matter with the lower extremity function recovery. Given the fact that the white matter is more resistant to ischemia after acute stroke than the gray matter (Falcao et al., 2004) and that the intensity of white matter in stroke has been found to be much greater in many brain areas in stroke than in healthy controls (Wen et al., 2004), it is of interest to study how the integrity of the subcortical white matter, primarily the corticospinal tracts and the corpus callosum, contributes to the recovery of lower extremity function in subacute and chronic stroke with lesions involving different areas of the brain.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: July 2009
• Est. primary completion date: June 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 30 Years to 80 Years

Eligibility

Inclusion Criteria:

• between 30 to 80 years old

• diagnosis of the first-time onset of stroke as confirmed by imaging studies

• within 30 days post onset University Hospital

• brain lesions mainly involving either the cortical primary motor cortex (M1) area or confined to the subcortical (M1 spared)

• No neurological or orthopedic problems which would affect their lower extremity function

• no contraindications for MRI studies

Exclusion Criteria:

• medically unstable

• unable to communicate with the experimenters

Study Design

Observational Model: Case Control, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Stroke

Locations

Country	Name	City	State
China	School and Graduate Institute of Physical Therapy College of Medicine, National Taiwan University	Taipei	Taiwan

Sponsors (2)

Lead Sponsor	Collaborator
National Taiwan University Hospital	National Science Council, Taiwan

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	clinical assessments, included balance, motor, walking,ADL, will be obtained for tests performed on D7, D30 and D90		D30, D90 and D180 post stroke onset	No