Stroke Due to Basilar Artery Occlusion Clinical Trial
Official title:
Acute Basilar Artery Occlusion: Endovascular Interventions vs Standard Medical Treatment
This trial will provide valuable insights into the safety and efficacy of endovascular treatment for acute ischemic stroke patients with basilar artery occlusion within 8 hours of estimated occlusion time.
This clinical trial is designed to compare the safety and efficacy of endovascular treatment
plus standard medical therapy with standard medical therapy alone for acute BA occlusion
presented within 8 h of estimated occlusion time. There is only one ongoing clinical
trial-Basilar Artery International Cooperation Study (BASICS) (NCT01717755) aimed to evaluate
the efficacy and safety of additional intra-arterial treatment after intravenous treatment in
750 patients with BA occlusion, which was anticipated to be completed in Oct 2017. Initiation
of intra-arterial therapy should be feasible within 6 hours of estimated time of BA
occlusion. And patients are required to have an NIHSS ≥ 10 at time of randomization, and take
IV rt-PA, age between 18-85 years old.
In this trial, the investigators did not have age or NIHSS score limit, patients who did not
fulfill the requirements for IV rt-PA can also be included into the trial, the investigators
also extended the time window to 8 hours which will accelerate the recruitment of potential
subjects. In endovascular treatment arm, the time interval between randomization to procedure
finish will be controlled within 120 mins. The preparation of endovascular treatment will
start immediately after randomization for those eligible patients for IV rt-PA within 4.5
hours after acute stroke onset, with no need to wait for the one-hour rt-PA infusion. A
positive trial will suggest substantial clinical benefit from endovascular treatment plus
standard medical therapy over standard medical therapy. This trial may provide novel evidence
of adopting endovascular treatment for acute patients with BA occlusion, which may
consequently advance our current approach for acute stroke treatment.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05827042 -
Endovascular Thrombectomy Alone Versus Intravenous Thrombolysis Plus Thrombectomy on Acute Basilar Artery Occlusion
|
Phase 3 | |
| Recruiting |
NCT05701956 -
Intravenous Tenecteplase Plus EVT Versus EVT Alone on 4.5 to 24 Hours After Basilar Artery Occlusion
|
Phase 3 | |
| Completed |
NCT04751708 -
Endovascular Treatment for Acute Basilar Artery Occlusion
|
N/A |