Stroke Clinical Trial
Official title:
Modulating Interaction of Motor Learning Networks in Rehabilitation of Stroke
This study uses a form on non-invasive brain stimulation called transcranial magnetic stimulation to understand 1) understand how the brain learns post-stroke and 2) assess non-invasive brain stimulation as an addition to current stroke rehabilitation approaches. In two study arms the investigators will compare the effect of active transcranial magnetic stimulation paired with motor practice with placebo (or sham) transcranial magnetic stimulation paired with the same motor practice.
Stroke is the leading cause of permanent disability in the United States. In the absence of
treatments to restore the lost tissue, clinical scientists have focused upon repetitive
forced used of the paretic limb to promote neural reorganization in preserved tissue and
reduce disability. However, forced use interventions are time intensive and the extent of
functional recovery is variable. One potential contributor to this variability is the
potential trade-off between compensatory cognitive motor control strategies and the extent of
procedural learning that can occur. Compensatory strategies adopted by patients may produce
quick short-term increases in performance but retard slower sustained improvements by
interfering with development of procedural learning. Consistent with this hypothesis, the
investigators' previous work documents an increased reliance upon dorsolateral prefrontal
cortex during performance of learned skills post-stoke. However, the investigators' previous
work also demonstrates that the effect of increased activity in dorsolateral prefrontal
cortex may limit reorganization in important areas involved in the consolidation of practice
thereby limiting functional recovery post-stroke.
Transcranial magnetic stimulation offers a unique opportunity to investigate the relationship
between dorsolateral prefrontal cortex activity and consolidation of motor
practice/rehabilitaion post-stroke. Here the investigators' objective is to determine whether
suppression of the contralesional dorsolateral prefrontal cortex, with continuous theta burst
transcranial magnetic brain stimulation (cTBS), a form of transcranial magnetic stimulation,
prior to motor practice enhances brain reorganization in critical areas and leads to greater
sustained improvements in motor ability over time.
The proposed work will enhance the understanding of motor learning post-stroke and provide
preliminary evidence for the benefits of dorsolateral prefrontal cTBS as an adjunct to
current rehabilitation interventions.
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