Depression Clinical Trial
Official title:
Mindfulness-Based Stress Reduction for Posttraumatic Stress Disorder: A Pilot Study
PTSD is a common consequence of war, for soldiers and civilians. PTSD results in
hyperarousal, avoidance, numbing, and re-experiencing, causing persistent decreased quality
of life. Mindfulness involves the ability to bring attention to the present moment without
judgment; this ability is correlated with measures of mental health. Within health care,
mindfulness is taught as an 8-week course called Mindfulness-Based Stress Reduction (MBSR).
MBSR is unstudied for PTSD. We propose to assess the feasibility of MBSR as an intervention
for PTSD, since it may affect hypervigilance, avoidance, and reactivity associated with this
disorder.
Specific Aims: Aim 1: Assess the feasibility of recruiting and retaining a sample of
veterans with PTSD to complete a study protocol that involves randomization to usual care or
usual care plus MBSR. Aim 2: Apply measures of PTSD symptom severity, depression and quality
of life before and after randomization, to assess whether there is evidence of benefit and
whether MBSR warrants further study for PTSD, and allow calculation of standardized effect
sizes. Aim 3: Apply a validated measure of mindfulness before and after treatment. Aim 4:
Explore the relationship between PTSD symptoms, mindfulness score, and frequency of
meditation practice.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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