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First Line Therapy for High Risk Acute GVHD

Stem Cell Transplant Complications Clinical Trial

Official title:
Ruxolitinib in Combination With Corticosteroid as First Line Therapy for the Treatment of High Risk Acute Graft-Versus-Host Disease

Clinical Trial Summary

The purpose of this study is to determine the efficacy and safety of combined Ruxolitinib With Corticosteroids as First Line Therapy for the Treatment of High risk aGVHD(acute graft-versus-host disease )

Clinical Trial Description

Acute graft-versus-host disease (aGVHD) is treated with systemic corticosteroid immunosuppression as first line therapy. Many patients with high risk aGVHD do not respond to primary therapy, high-dose systemic corticosteroids; therefore, survival for those patients remains particularly poor. Here we determine the efficacy and safety of combined Ruxolitinib With Corticosteroids as First Line Therapy for the Treatment of High risk aGVHD. ;

Study Design

Related Conditions & MeSH terms

  • aGVHD
  • Stem Cell Transplant Complications
Clinical Trial Details
NCT number NCT04061876
Study type Interventional
Source Chinese PLA General Hospital
Contact
Status Completed
Phase Phase 2
Start date August 25, 2019
Completion date June 30, 2023
View Details
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