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Clinical Trial Summary

This is multicenter investigator-initiated randomized open-label phase II clinical trial to compare prophylaxis of graft versus host disease treated with tacrolimus and mycophenolate mofetil versus ruxolitinib after post-transplant cyclophosphamide. In total 128 patients will be included in the study. After inclusion into the study and performing of transplantation patients will be randomized in 1:1 proportion in two arms (64 patients per arm): arm A will include patients who will be treated with cyclophosphamide and ruxolitinib for GVHD prophylaxis; arm B will include patients who will be treated with cyclophosphamide, tacrolimus and MMF for GVHD prophylaxis. After the end of the treatment patients will be followed-up during two years.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04669210
Study type Interventional
Source St. Petersburg State Pavlov Medical University
Contact
Status Active, not recruiting
Phase Phase 2
Start date November 3, 2020
Completion date February 2025

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