Effect of Stellate Ganglion Block on New Atrial Fibrillation After Coronary Artery Bypass Grafting

Stellate Ganglion Block Clinical Trial

Official title:

Effect of Stellate Ganglion Block on New Atrial Fibrillation After Coronary Artery Bypass Grafting

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05932485
• Other study ID #: 20230609
• Status: Recruiting
• Phase: N/A
• Start date: June 1, 2023
• Est. completion date: June 1, 2024

Study information

• Verified date: July 2023
• Source: Yangzhou University
• Contact: Zhuan zhang, professor
• Phone: +8615062791355
• Email: zhangzhuancg[@]163.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Post-operative new-onset atrial fibrillation (POAF) is one of the most common arrhythmias in adults after direct intracardiac surgery with extracorporeal circulation. The incidence of POAF in coronary artery bypass grafting (CABG) is approximately 30%. POAF can lead to an increased risk of complications such as stroke, heart failure, and acute kidney injury, which not only prolongs the patient's hospital stay, but also increases hospital costs and mortality. operation, extracorporeal circulation, and the patient's underlying conditions (such as age, gender, hypertension, and diabetes), which cause sympathetic activation, inflammatory response, and myocardial ischemia in the organism. The stellate ganglion block (SGB) regulates the sympathetic tone of the innervated nerves and thus the autonomic function of the body. SGB can effectively regulate the sympathetic-parasympathetic imbalance. Also, SGB may exert some anti-inflammatory effects. In this study, ultrasound-guided SGB was used in CABG patients to investigate its effect on the occurrence of POAF.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 60
• Est. completion date: June 1, 2024
• Est. primary completion date: December 1, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Patients undergoing first-time and elective coronary artery bypass grafting;

• ASA grade II-IV;

• The preoperative ECG showed sinus heart rate.

Exclusion Criteria:

• The patient refused to participate in this study;

• Surgical procedures include any other type of heart surgery in addition to CABG;

• Allergic to known general anesthesia drugs;

• Patients with a history of neck surgery or abnormal neck anatomy;

• Patients with contraindications to SGB.

Related Conditions & MeSH terms

• Atrial Fibrillation
• Ganglion Cysts
• Stellate Ganglion Block

Intervention

Procedure:
• Stellate nerve block
Before the operation, the left stellate ganglion block was performed, and 0.375% ropivacaine 5ml was injected into the stellate ganglion.

Locations

Country	Name	City	State
China	the Affiliated Hospital of Yangzhou University, Yangzhou University	Yangzhou	Jiangsu

Sponsors (1)

Lead Sponsor	Collaborator
Yangzhou University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The occurrence of new atrial fibrillation was detected by ECG monitoring	ECG monitor shows atrial fibrillation. To be specific: 1)Irregular R-R interval (when atrioventricular conduction is present), 2) P wave disappearance, 3) irregular atrial activity.	Within 5 days after surgery
Secondary	Changes in the inflammatory factor interleukin-6	Detection of inflammatory factors by serum,It reflects the degree of inflammation in the body at different time points	Preoperatively, End of operation ,The first day after surgery, The Third day after surgery
Secondary	Changes in the Stress index cortisol	Detection of Stress index by serum,It reflects the degree of stress in the body at different time points	Preoperatively, End of operation ,The first day after surgery, The Third day after surgery