Differential Effects of Lipids on Cardiovascular Diseases: A CALIBER Study

Stable Angina Clinical Trial

Official title: Differential Effects of Total Cholesterol, Non-HDL Cholesterol and Triglycerides on Initial Presentation of Specific Cardiovascular Diseases (a CALIBER Study)

Status Active, not recruiting

Clinical Trial Summary

The role of lipids as risk factors for cardiovascular events is well-documented, although events studied have largely been broad classes without specific detail. This study will examine a more refined set of endpoints.

Clinical Trial Description

The role of lipids (cholesterol and triglycerides) as risk factors for cardiovascular events is well-documented. The Emerging Risk Factors Collaboration found approximately log-linear adjusted associations of cholesterol concentrations with risks of first-time non-fatal myocardial infarction; coronary heart disease (CHD) death; ischaemic, haemorrhagic and unclassified stroke. They also found that triglycerides concentration was not independently related with CHD risk after controlling for HDL cholesterol (HDL-C), non-HDL-C, and other standard risk factors. The Prospective Studies Collaboration found that Higher HDL-C and lower non-HDL-C levels were approximately independently associated with lower ischaemic heart disease mortality. By focusing on broad outcomes these large meta-analyses conflate the association between development of the different cardiovascular disease (CVD) phenotypes, disease progression and mortality from cardiovascular causes.

With linked electronic health records, we have the potential for a cohort with sufficient size and clinical detail to investigate the association between lipid concentrations and initial presentation of a range of CVD phenotypes across cerebral, coronary, abdominal and peripheral arterial circulations. ;

Study Design

Observational Model: Cohort, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Angina, Stable
• Angina, Unstable
• Cardiovascular Diseases
• Infarction
• Myocardial Infarction
• Myocardial Infarction Not Otherwise Specified
• Non ST Elevation Myocardial Infarction
• ST Elevation Myocardial Infarction
• Stable Angina
• Unstable Angina

• NCT number: NCT01687686
• Study type: Observational
• Source: University College, London
• Status: Active, not recruiting
• Phase: N/A
• Start date: January 2001
• Completion date: December 2012