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Spine Fusion clinical trials

View clinical trials related to Spine Fusion.

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NCT ID: NCT06154980 Recruiting - Pain Clinical Trials

Randomized Controlled Comparison of Pre-op TLIP vs Intra-op TLIP

Start date: April 2024
Phase: N/A
Study type: Interventional

Single-center, randomized study will enroll 50 subjects who are scheduled for 1-3 level posterior laminectomy & fusion. Study participants who are eligible for the posterior lumbar laminectomy and fusion procedure will be scheduled and also consented as a part of the study. Participants will be stratified based on age and gender to ensure equal distribution.

NCT ID: NCT06140927 Recruiting - Spinal Stenosis Clinical Trials

Effect of Ketamine on Intraoperative Motor Evoked Potentials

Start date: December 1, 2023
Phase: Phase 3
Study type: Interventional

The goal of this clinical trial is to learn about the effect of ketamine on intraoperative motor evoked potentials in adult patients undergoing thoracolumbar spinal fusions. Participants will undergo a standard anesthetic. In addition to the standard anesthetic, the patients will be administered increasing doses of ketamine with motor-evoked potentials being measured at each dose, to assess any impacts.

NCT ID: NCT06140797 Not yet recruiting - Frailty Syndrome Clinical Trials

Pre-operative Risk Assessment Combined With Targeted Intervention in Chinese Elderly With Spine Surgery

PRACTICE
Start date: January 1, 2024
Phase: N/A
Study type: Interventional

With the extended life expectancy of the Chinese population and improvements in surgery and anesthesia techniques, the number of aged patients undergoing surgery has been increasing annually. However, safety, effectiveness, and quality of life of aged patients undergoing surgery are facing major challenges. This study aims to develop a perioperative multidisciplinary evaluation system for aged patients over 75 years undergoing surgery, which could identify and stratify risks, formulate preoperative, intraoperative and postoperative intervention strategies. The investigators will conduct a perioperative risk evaluation and targeted intervention, with follow-ups at 1, 3, and 6 months after surgery. The primary goal of this study is to develop a CGA-based calculator for predicting adverse events after spinal fusion surgery in patients aged 75 and over, and evaluate the importance of several common CGA items to predict postoperative complications and poor postoperative recovery. The secondary objective is to construct a new perioperative management protocol which includes pre-operative risk assessment and targeted intervention.

NCT ID: NCT06107660 Not yet recruiting - Anesthesia, Local Clinical Trials

Utility of Exparel Based ESP Blocks in Elective Posterior Spine Fusion

Start date: December 2023
Phase: Phase 4
Study type: Interventional

The goal of this clinical trial is to compare two different medications used to reduce pain during lower back fusion surgery. The main questions this study aims to answer are: 1. Can liposomal bupivacaine, when included in a regional anesthesia technique called the Erector Spinae Plane block (ESPB), reduce opioid use post-operatively compared to the standard medication typically used in an ESPB (bupivacaine with stabilizing agents)? 2. Do patients report lower pain and better satisfaction with their surgery when they receive liposomal bupivacaine in the ESPB compared to those that receive the standard medication? Participants will be randomized to into two groups one that receives liposomal bupivacaine and one group that receives bupivacaine with stabilizing agents. Other than the randomization all patients will follow current standard of care at our hospital, and will not be asked to complete any additional study forms in addition to forms currently asked of all patients as per standard of care.

NCT ID: NCT06102681 Recruiting - Clinical trials for Lumbar Disc Herniation

Examination of the Effect of Early Mobilization on Postoperative Recovery, Pain, Quality of Life and Complication Development in Elective Minimally Invasive Spine Surgery

Start date: November 27, 2023
Phase: N/A
Study type: Interventional

Accelerated Postoperative Recovery (ERAS) is a multidisciplinary approach aimed at facilitating faster and more effective recovery for patients undergoing surgical procedures. The ERAS protocol encompasses specific measures implemented during the preoperative, intraoperative, and postoperative phases. Its goal is to enable patients to achieve better outcomes by reducing postoperative pain, complications, and hospital stays. The multimodal and multidisciplinary approach to patient care during the perioperative period includes a combination of evidence-based interventions designed to reduce the stress of surgery to maintain anabolic homeostasis and promote recovery. This approach involves preparing patients for surgery through assessment and education, optimizing intraoperative management (such as minimally invasive surgery, pain control, and optimal fluid management), and expediting postoperative recovery (e.g., through early feeding and mobilization). Early mobilization is considered a crucial element of this approach and is strongly recommended as part of ERAS guidelines across various surgical disciplines. Prolonged bed rest following surgical treatment has been associated with adverse outcomes, such as thromboembolism, pneumonia, muscle weakness, and loss of physical conditioning. If a patient does not have physical limitations in the postoperative period, early ambulation benefits in the preservation of respiratory, circulatory, musculoskeletal, and gastrointestinal system functions, as well as in reducing complications related to anesthesia and surgery. Ultimately, it accelerates recovery, enables early discharge, reduces hospital costs, and lightens the workload of healthcare professionals.

NCT ID: NCT06082245 Completed - Analgesia Clinical Trials

TLIP Block and ESP Block For Perioperative Analgesia In Patients With Lumbar Spine Fusion Surgery

Start date: October 1, 2021
Phase: N/A
Study type: Interventional

Background: Pain relief for lumbar spine surgery is being updated to help improve the quality of post-operative recovery, especially ultrasound-guided pain relief anesthesia methods, including two anesthesia methods. Thoracolumbar interfascial plane block (TLIP block) and erector spinae plane block (ESP block) are increasingly commonly applied. Objective: compare the pain relief effectiveness of TLIP block with ESP block for lumbar spine surgery. Methods: Randomized prospective intervention study conducted at Hanoi Medical University Hospital from October 2021 to October 2022 including 100 lumbar spine surgery patients randomly divided into three groups: group control, TLIP group and ESP group. Outcomes regarding perioperative pain score (ANIm, VAS), the effectiveness of 2 ultrasound-guided methods, the complications and the side effects were recorded.

NCT ID: NCT06059820 Not yet recruiting - Spine Fusion Clinical Trials

Effectiveness of Conservative Treatment in Patients With Thoracic and Lumbar Fractures Without Neurological Deficit

Start date: October 1, 2023
Phase:
Study type: Observational

The goal of this observational study is to compare the long-term clinical outcomes of two treatment methods (conservative therapy and surgical treatment) in patients with fractures of the thoracic and lumbar spine without neurological deficit

NCT ID: NCT05986006 Enrolling by invitation - Spine Surgery Clinical Trials

Fusion Status After ACDF

Start date: August 7, 2023
Phase: N/A
Study type: Interventional

Pseudarthrosis, a failure of bony fusion, is one of the most common causes of revision surgery following anterior cervical discectomy and fusion (ACDF). The interbody spacer is an important component of bony fusion in ACDF, and we aim to compare machined allograft spacers versus iliac crest allograft in a randomized controlled trial.

NCT ID: NCT05957822 Not yet recruiting - Prostate Cancer Clinical Trials

Goal-directed vs Preemptive Tranexamic Acid Administration in Non-cardiac Surgery

Start date: November 1, 2023
Phase: Phase 4
Study type: Interventional

The present study is a multi-center randomized prospective non-inferiority trial. The study's primary objective is to compare the coagulation profile upon using two different TXA administration strategies: empirical TXA administration vs. viscoelastic test-based goal-directed TXA administration in high-risk non-cardiac surgery. The secondary objectives include comparing the amount of bleeding, incidents of hyper-fibrinolysis, thromboembolic complications, and postoperative seizures. Researchers assumed that goal-directed tranexamic acid (TXA) administration using viscoelastic field tests would not be inferior to the empirical TXA administration strategy in reducing postoperative bleeding and hyper-fibrinolysis. It also would be beneficial in lowering TXA-induced thromboembolic complications and seizures.

NCT ID: NCT05850468 Not yet recruiting - Opioid Use Clinical Trials

Effectiveness of Combining Erector Spinea Block With Non Opioid Infusions as Opioid Free Anesthesia in Spine Surgeries.

Start date: May 2023
Phase: N/A
Study type: Interventional

opioid free anesthesia consists of combination of pharmacological and non pharmacological modalities that target different pathways of pain mechanism. combining myofascial plane blocks with infusion of adjuvants such as lidocaine or dexmedetomidine can offer equivalent intraoperative hemodynamic stability compared to that of opioid with better pain control postoperatively. this study will investigate the efficacy of combined erector spina block with lidocaine and dexmedetomidine infusion as opioid sparing anesthesia in spine surgeries