Spinal Metastases Clinical Trial
Official title:
A Phase II Randomized Trial of Combined Radiotherapy and Vertebroplasty to Improve the Quality of Life of Patients With Painful Metastatic Localized Spinal Lesions
Since patients with spinal metastases are living longer, durable palliation with long-term tumor control are becoming increasingly important. EBRT results in durable local control of bone metastasis. However, about 25 % of patients with spinal metastases only achieved complete pain relief following EBRT for a median duration of less than 4 months. This could be partly due to spinal instability. In addition, almost half of the patients who receive EBRT will subsequently develop VCFs . Hence, RT does not stabilize the spine secondary to VCFs and is not effective in preventing imminent VCFs. Vertebroplasty has rapidly reduced pain and improved function in patients with VCFs. However, vertebroplasty does not provide local tumor control similar to EBRT. It is theorized that combining vertebroplasty with EBRT will stabilize the spine, relieve the pain, prevent imminent VCFs and minimize or avoid the need for opioids. It is hypothesized that combining a spine stabilization procedure such as vertebroplasty with RT will be the most effective management for patients with spinal metastases than RT alone for patients with spinal metastases. Combined vertebroplasty and radiotherapy is not a standard treatment option at present. This study is designed to quantify the advantage of adding vertebroplasty to radiotherapy for patients with spinal metastases. If the study is proven to be significant, it could become the standard of care for patients with spinal metastases.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT01347307 -
Stereotactic Body Radiotherapy for Spine Tumors
|
N/A | |
Terminated |
NCT00593320 -
Stereotactic Radiosurgery (SRS) for Spine Metastases
|
N/A | |
Recruiting |
NCT05575323 -
Randomized Trial on Same-day SBRT and Surgical Stabilization for Symptomatic Spinal Metastases
|
N/A | |
Completed |
NCT02987153 -
Kypho-Intra Operative Radiation Therapy (IORT) for Localized Spine Metastasis, Phase I/II Study
|
N/A | |
Recruiting |
NCT03363685 -
Verification of Novel Survival Prediction Algorithm for Patients With NSCLC Spinal Metastasis
|
||
Terminated |
NCT02407795 -
Conventional With Stereotactic Radiotherapy for Pain Reduction and Quality of Life in Spinal Metastases
|
N/A | |
Completed |
NCT01365715 -
Preoperative Embolization in Surgical Treatment of Spinal Metastases.
|
N/A | |
Recruiting |
NCT04863612 -
SBRT in the Management of Solid Spinal Metastases
|
||
Recruiting |
NCT01849510 -
Efficacy of Dose Intensified Radiotherapy of Spinal Metastases by Hypofractionated Radiation and IGRT hfSRT Mediated Boost
|
Phase 2 | |
Not yet recruiting |
NCT06244264 -
The Safety and Efficacy of Autologous Transfusion in Spinal Surgery for Lung Cancer With Spinal Metastasis
|
N/A | |
Not yet recruiting |
NCT06220071 -
Multicentric European Study In Patients With Vertebral Metastases
|
||
Completed |
NCT01290562 -
Stereotactic Body Radiotherapy (SBRT) for Spinal/Para-Spinal Metastases (Spine SBRT)
|
Phase 2 | |
Recruiting |
NCT06120426 -
En Bloc Resection Versus Separation Surgery Combined With Radiotherapy for the Treatment of Spinal Oligometastatic Tumor.
|
||
Completed |
NCT03224650 -
Validation of Novel Predictive Score for Patients With Spinal Metastases
|
||
Completed |
NCT02512965 -
Study Comparing Stereotactic Body Radiotherapy vs Conventional Palliative Radiotherapy (CRT) for Spinal Metastases
|
N/A | |
Not yet recruiting |
NCT06093854 -
Intraoperative Radiotherapy in Treating Spinal Metastases
|
N/A | |
Completed |
NCT02364115 -
Randomized Trial Comparing Conventional Radiotherapy With Stereotactic Radiotherapy in Patients With Bone Metastases - VERTICAL Study
|
N/A | |
Recruiting |
NCT03398915 -
The European Robotic Spinal Instrumentation (EUROSPIN) Study
|
||
Not yet recruiting |
NCT05173467 -
Robot-assisted Invasion-controlled Surgery Versus Traditional-open Surgery Against Metastatic Spinal Tumor
|
N/A | |
Recruiting |
NCT04248543 -
Quantitative MRI for Functional Assessment Following SBRT for Spinal Metastases
|
N/A |