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Quantitative MRI for Functional Assessment Following SBRT for Spinal Metastases

Spinal Metastases Clinical Trial

Official title:
Quantitative MR Imaging Methods for Functional Assessment Following Stereotactic Body Radiation Therapy for Spinal Metastases

Clinical Trial Summary

The purpose of this study is to determine if quantitative magnetic resonance imaging (qMRI) can objectively measure changes in the tumor/vertebral body and adjacent spinal cord following stereotactic body radiation therapy (SBRT) for painful metastatic spine disease.

Clinical Trial Description

Metastatic spine disease (MSD) can result in considerable morbidity from pain, spinal cord compromise and neurologic disability. Recent developments in image-guidance and immobilization have enabled more accurate target localization, which allows methods of precise high-dose radiation delivery such as stereotactic body radiation therapy (SBRT). SBRT carries potential risks of radiation induced myelopathy (RIM) and vertebral compression fracture (VCF). Magnetic resonance imaging (MRI) is a sensitive imaging modality that may be able to detect radiation-induced damage in the vertebral body or spinal cord following SBRT. Quantitative MR-based imaging methods may also help to quantify treatment response and help predict subsequent outcomes such as tumor control and VCF risk. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04248543
Study type Interventional
Source Duke University
Contact Taylor Fryman, BS
Phone (919) 668-3726
Email taylor.fryman@duke.edu
Status Recruiting
Phase N/A
Start date December 22, 2020
Completion date December 2024
View Details
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