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Spinal Cord Injuries clinical trials

View clinical trials related to Spinal Cord Injuries.

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NCT ID: NCT03898700 Completed - Clinical trials for Spinal Cord Injuries

Coaching for Caregivers of Children With Spinal Cord Injury

Start date: September 28, 2018
Phase: N/A
Study type: Interventional

This pilot study has two aims. The first aim is to establish the feasibility of coaching for caregivers of youth with spinal cord injury, and the second aim is to establish methodological procedures for a future multi-center study on the effectiveness of coaching as an intervention for caregivers of youth with spinal cord injury.

NCT ID: NCT03898258 Completed - Clinical trials for Spinal Cord Injuries

Evaluation of the German Short-Form Qualiveen Questionnaire

Start date: August 2, 2019
Phase:
Study type: Observational

Two questionnaires (Qualiveen full version and Qualiveen short-form (SF)), the project information and the consent form will be sent to individuals who are scheduled for an annual control at the urological out-patient clinic of the Swiss Paraplegic Centre and who fulfill the inclusion criteria. The patients will be asked to complete the two questionnaires and to bring the completed questionnaires and the signed consent form to the annual control at the Swiss Paraplegic Centre. Participants who have consented and completed the two questionnaires will receive the two questionnaires a second time 14 days later. The primary objective of this project is to validate the German version of the SF Qualiveen questionnaire. The secondary objective is to evaluate the measurement properties of the German SF Qualiveen questionnaire in comparison with the full version.

NCT ID: NCT03886857 Completed - Clinical trials for Spinal Cord Injuries

Segmental Mechanisms of Transcutaneous Spinal Cord Stimulation for Spasticity Control

SCS_CorE_AT
Start date: May 1, 2019
Phase: N/A
Study type: Interventional

The aim of the pilot study is to gain first insights into the interaction of transcutaneous spinal cord stimulation with the altered activity of intraspinal circuits associated with spinal spasticity. The main goal is to evaluate the validity of the chosen measures and to generate a data base for statistical planning of a subsequent clinical study.

NCT ID: NCT03886610 Completed - Clinical trials for Spinal Cord Injuries

Association of Quantitative and Functional Imaging With Clinical Outcome After Spinal Cord Injury

Start date: March 27, 2019
Phase:
Study type: Observational

The overall study aim is to provide additional magnetic resonance imaging parameters of the cervical spinal cord, brainstem and brain and a better understanding of changes after spinal cord injury (SCI) and to define new magnetic resonance (MR) biomarkers to correlate with sensomotoric functioning and clinical outcome.

NCT ID: NCT03875066 Completed - Clinical trials for Spinal Cord Injuries

Immediate Effects of Stepping Training Using External Feedback in Spinal Cord Injury Patients

Start date: April 19, 2017
Phase: N/A
Study type: Interventional

- Does stepping training with or without external feedback change functional ability of ambulatory patients with iSCI immediately after training? - Are there significant differences between the immediate effects of stepping training with or without external feedback in ambulatory patients with iSCI?

NCT ID: NCT03863379 Completed - Stroke Clinical Trials

Sarcopenic Obesity in Neurodisabilities

SarcObeNDS
Start date: May 2, 2019
Phase:
Study type: Observational

To describe the frequency and thresholds for sarcopenic obesity in neurodisabled persons and the fat and lean mass distribution based on various neurodisabilities

NCT ID: NCT03859960 Completed - Clinical trials for Spinal Cord Injuries

The Effects of Spasticity on Glucose Metabolism in Individuals With Spinal Cord Injury

Start date: September 21, 2014
Phase:
Study type: Observational

Muscle atrophy may occur in individuals with spinal cord injury (SCI) as a result of diminished physical activity and alterations in glucose metabolism and body composition may be seen. In a few studies, it has been suggested that spasticity may have a positive impact on glucose metabolism by preventing muscle atrophy and alterations in body composition in individuals with motor complete SCI. Investigators aimed to assess the effects of spasticity on glucose metabolism and body composition in participants with complete and incomplete SCI.

NCT ID: NCT03857672 Completed - Chronic Pain Clinical Trials

The Efficacy of Hypnotic Cognitive Therapy for Chronic Pain in SCI

Start date: April 24, 2019
Phase: N/A
Study type: Interventional

Chronic pain is prevalent and disabling in people with spinal cord injury (SCI). Medications alone often do not cure the pain. Pilot research suggests that training in the combination of self-hypnosis and cognitive therapy (HCT) can reduce chronic SCI-related pain. Thus far, people have learned HCT only through in-person training sessions plus home practice. The investigators think that training in HCT could be as effective if the training is done via videoconferencing. The purpose of this study is to find out whether people who are trained in HCT via videoconferencing achieve significant pain relief and other benefits compared to people who receive usual medical care (UC) for pain. Bettering our understanding of videoconferencing-delivered HYPNOCT can greatly increase treatment accessibility for individuals with SCI. Aim 1: To compare the efficacy of HYPNOCT vs. UC in adults with SCI and chronic pain. Investigators will compare the effect of the intervention on patient-reported average daily pain as measured by a 0-10 numerical rating scale. Aim 2: To examine sex, race/ethnicity, and pain type (neuropathic vs. non-neuropathic) as potential effect modifiers. Hypotheses Primary study hypothesis Hypothesis 1a: There will be a significantly greater reduction in average daily pain intensity from baseline to the end of treatment in the HYPNOCT group compared to the UC group. Secondary study hypotheses Hypothesis 1b: Compared to the UC group, participants in the HYPNOCT group will show greater improvement in pain interference, depression, sleep quality, subjective disability, health-related quality of life, community participation, pain catastrophizing, pain acceptance, and global improvement. Hypothesis 2: The investigators will examine whether sex, race/ethnicity, and pain type (neuropathic vs. non-neuropathic) exert a modifying effect upon outcomes.

NCT ID: NCT03854214 Completed - Clinical trials for Spinal Cord Injuries

Investigation of Brain Functional MRI as an Early Biomarker of Recovery in Individuals With Spinal Cord Injury

Start date: August 1, 2019
Phase: N/A
Study type: Interventional

Early detection of response to therapeutic intervention is vital, as it will enable early termination of intervention in non-responding patients, prevent unnecessary financial burden, and allow for early changes to the intervention program. Previous functional MRI (fMRI) studies have shown that changes in brain functional network in spinal cord injury (SCI) patients can occur after as little as one week of intervention. Resting state fMRI (rsfMRI) is a type of fMRI that does not require performance of explicit motor tasks, which makes the method especially suitable for SCI patient population. In this project, the investigators propose that rsfMRI outcome measures can be used to detect early brain functional network changes that occur during intervention, and that the changes will be predictive of recovery in chronic SCI patients.

NCT ID: NCT03851302 Completed - Clinical trials for Spinal Cord Injuries

Effects of Remote Ischemic Conditioning on Hand Use in Individuals With Spinal Cord Injury and Amyotrophic Lateral Sclerosis

Start date: October 28, 2019
Phase: N/A
Study type: Interventional

Rehabilitation interventions such as physical training and neural stimulation after spinal cord injury (SCI) have been shown to increase neural plasticity. However, both physical training and neural stimulation require a large number of repetitions, and the retention of the intervention effects may be fleeting. In this proposal the investigators will test Remote ischemic conditioning (RIC), which has been shown to promote neural plasticity and has practical and theoretical advantages. RIC consists of transiently restricting blood flow to any 'remote' limb using a blood pressure cuff. This induces several of the body's systemic defensive reactions. RIC has been shown to improve motor learning. The investigators propose that RIC alters motor pathway excitability through a combination of systemic increases in plasticity-promoting factors and inhibition of inflammatory factors. The investigators have designed a clinical trial to test this hypothesis in 8 persons with SCI and 8 able-bodied controls. All participants will receive active/sham RIC plus a hand exercise. The investigators will measure effects on blood pressure, motor neuron excitability, and systemic inflammatory markers before and after RIC as well as after hand exercise. Starting July 2021, we will also enroll 5 individuals with Amyotrophic lateral sclerosis (ALS) in this study.