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Spinal Cord Compression clinical trials

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NCT ID: NCT01256554 Completed - Clinical trials for Metastatic Epidural Spinal Cord Compression

Single Session Spine Stereotactic Radiosurgery in Metastatic Epidural Spinal Cord Compression

Start date: December 3, 2010
Phase: Phase 1
Study type: Interventional

The goal of this clinical study is to learn the feasibility of using a single session of radiation, known as spine stereotactic radiosurgery (SSRS), to treat metastatic epidural spinal cord compression.

NCT ID: NCT00974168 Completed - Pain Clinical Trials

Spinal Cord Compression Re-Treat Study

Start date: October 2007
Phase: Phase 2
Study type: Interventional

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Radiation therapy may be effective in treating malignant spinal cord compression in patients who have received previous radiation therapy to the spine. PURPOSE: This phase II trial is studying radiation therapy in treating patients with malignant spinal cord compression.

NCT ID: NCT00968643 Completed - Clinical trials for Unspecified Adult Solid Tumor, Protocol Specific

Spinal Cord Compression. ICORG 05-03, V6

Start date: January 2006
Phase: Phase 3
Study type: Interventional

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known which radiation therapy schedule is more effective in treating patients with malignant spinal cord compression. PURPOSE: This randomized phase III trial is studying two different radiation therapy schedules to compare their side effects and how well they work in treating patients with malignant spinal cord compression.

NCT ID: NCT00928382 Completed - Cancer Clinical Trials

A Pilot Study to Explore Serum and Imaging Biomarkers in Patients With Spinal Cord Compression

Start date: March 31, 2009
Phase: N/A
Study type: Observational

One of the complications of having cancer in the spinal vertebrae is that it can spread and lead to compression of the spinal cord. Spinal cord compression is a serious event that needs to be treated quickly in order to prevent permanent damage to the spinal cord and nerves. - Researchers currently do not have the ability to accurately predict whether cancer of the vertebrae will cause spinal cord compression. It is possible that accurate predictions could allow doctors to treat patients even before they develop symptoms of spinal cord compression, thereby preventing some of the long-term consequences. Objectives: - To compare patients with cancer of the spinal vertebrae with and without symptoms of spinal cord compression by looking at markers in the blood and changes on novel magnetic resonance imaging (MRI) techniques that might allow researchers to predict who will experience spinal cord compression before they actually begin to have symptoms. Eligibility: - One group of healthy volunteers 18 years of age and older. - One group of patients 18 years of age and older who have cancer that has spread to the vertebrae without symptoms of spinal cord compression. - One group of patients 18 years of age and older who have cancer that has spread to the vertebrae with symptoms of spinal cord compression. Design: - Healthy volunteers: - Blood will be drawn from each volunteer for initial tests and for more specific biomarker tests. - Comprehensive MRI of the spine, followed by a special type of MRI called diffusion tensor imaging (DTI). It is believed that DTI may be even more sensitive in revealing spinal cord abnormalities than regular MRI sequences. - Patients with cancer of the vertebrae: - Researchers will obtain information such as pathology reports, laboratory results, diagnosis and treatment history, physical exam (PE) information, results of scans such as x-rays, MRI, computerized tomography (CT), and positron emission tomography (PET), and planned treatment details. - Additional blood samples will be taken for specific biomarker tests. - Questionnaire about pain, unusual sensations or numbness, bladder or bowel problems, and mobility. - Comprehensive MRI of the spine, followed by a DTI. - Patients who appear to have symptoms of spinal cord compression will be offered standard radiation treatment.

NCT ID: NCT00727584 Completed - Clinical trials for Unspecified Adult Solid Tumor, Protocol Specific

Radiation Therapy in Treating Patients With Metastatic Spinal Cord Compression

Start date: November 2007
Phase: N/A
Study type: Interventional

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known which radiation therapy regimen is more effective in treating metastatic spinal cord compression. PURPOSE: This randomized clinical trial is comparing two radiation therapy regimens to see how well they work in treating patients with metastatic spinal cord compression.

NCT ID: NCT00634426 Completed - Clinical trials for Metastatic Epidural Spinal Cord Compression

Surgical Versus Nonoperative Treatment of Metastatic Epidural Spinal Cord Compression

MESCC
Start date: March 2008
Phase: Phase 4
Study type: Observational

The aim of this trial is to evaluate the differences in pain relief, neurological function, quality of life and survival in patients with metastatic epidural spinal cord compression (MESCC) who are managed with a combination of surgery and radiotherapy versus radiotherapy alone. Further we shall evaluate cost-effectiveness of the two treatment approaches.

NCT ID: NCT00280306 Completed - Clinical trials for Spinal Cord Compression

White Matter Fiber Tracking and Assessment of White Matter Integrity in the Cervical Spinal Cord

Start date: November 2005
Phase: N/A
Study type: Observational

White matter fiber tracking may provide a novel tool to assess the integrity of injured motor tracts in the cervical spine. It provides information about fiber directions which is not given by conventional MRI. White matter fiber tracking in the brain is used at several institutions, including our own medical college, for presurgical planning of tumor excision. We believe that the technical and clinical experience gained for the brain can be applied to fiber tracking in the cervical spine as well.

NCT ID: NCT00193869 Completed - Clinical trials for Spinal Cord Compression From Neoplasm Metastasis

SuperDEX Trial (Comparison of Two Doses of Dexamethasone for Malignant Spinal Cord Compression Treated by Radiotherapy).

Start date: September 2001
Phase: Phase 2
Study type: Interventional

The study aimed to pilot the viability of a full scale randomised comparison of 2 steroid doses in malignant spinal cord compression, to establish safety of high dose dexamethasone in this setting in Australia, to test web registration and randomisation and to compare different functional outcome measures.