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Sperm DNA Fragmentation clinical trials

View clinical trials related to Sperm DNA Fragmentation.

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NCT ID: NCT06231589 Completed - Infertility Clinical Trials

PGT-A Evaluates Advanced Sperm Selection in Embryos From High Teratozoospermia Males

Start date: January 1, 2023
Phase: N/A
Study type: Interventional

In this study of 264 couples, sperm selection techniques in males with high teratozoospermia index and sperm DNA fragmentation significantly increased fertilization, blastocyst development rates, and maintained comparable embryo euploidy rates through preimplantation genetic testing, suggesting the efficiency of these techniques in improving assisted reproductive outcomes.

NCT ID: NCT05508217 Recruiting - Sperm Clinical Trials

Impact of Telomere Biology and Sperm DNA Fragmentation on Embryonic Development

Start date: August 22, 2022
Phase:
Study type: Observational

The proposed project we intend to assess the implication of the telomeric pathway in male infertility. To get this, several analyzes will be carried out: 1. Determination of the TL by means of two methods: Q-FISH and PCR. 2. Determination of sperm DNA fragmentation by tunnel technique. 3. Assess sperm maturation. Finally, the correlations between age, normality or not of the seminogram, LT, Short telomers (ST) accumulation, DNA fragmentation levels, sperm maturation and fertility, blastocyst development, and pregnancy rates will be established in search of cut-off points that can give a forecast of man´s fertility who consults on this subject.

NCT ID: NCT05494216 Completed - Infertility Clinical Trials

Advanced Sperm Selection Techniques and Their Contribution to Blastocyst Euploidy Rates

Start date: August 1, 2022
Phase: N/A
Study type: Interventional

Comparing different advanced sperm selection techniques like Physiological ICSI (PICSI) and magnetic activated cell sorting (MACS) in terms of the PGT-A outcomes of each arm blastocysts

NCT ID: NCT03668106 Terminated - Clinical trials for Sperm DNA Fragmentation

Effect of Different Sperm Processing Methods in ICSI Outcome.

Start date: May 1, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

A total 180 semen samples from couples diagnosed with unexplained infertility were SDF index tested , then total 120 semen samples of patients' husbands with abnormal SDF index were randomly divided and then processed by swim up, sperm gradient centrifugation and Zeta methods. SDF and ICSI outcomes are monitored after semen processing.

NCT ID: NCT03527043 Recruiting - Infertility, Male Clinical Trials

Impact of Escitalopram on Sperm DNA Fragmentation

Start date: October 1, 2017
Phase: Phase 2
Study type: Interventional

Double-blind placebo-controlled randomized trial of daily escitalopram for 6 weeks in healthy men with normal semen analyses and no psychiatric history of depression, bipolar, mania or suicidal ideation. Hormone profiles, semen analysis, sperm DNA fragmentation, and sexual function will be measured at baseline, after 6 weeks of therapy, and 4 weeks after discontinuation of therapy (10 weeks into study).

NCT ID: NCT03398317 Completed - Clinical trials for Sperm DNA Fragmentation

Sperm Selection by Either PICSI or MACS in Cases With Abnormal Sperm DNA Fragmentation Index for ICSI

Start date: January 1, 2017
Phase: N/A
Study type: Interventional

On the day of ICSI, choosing the best sperm by either PICSI or magnetic activated cell sorting (MACS) in cases with abnormal DNA is not fully investigated. This study helps in solving this problem by using two known techniques to achieve that purpose.

NCT ID: NCT03085433 Completed - Infertility Clinical Trials

Sperm Selection by Microfluidic Separation Improves Embryo Quality

SPERM
Start date: March 17, 2017
Phase: N/A
Study type: Interventional

This is a randomized controlled trial of couples with a history of poor embryo quality undergoing a repeat in vitro fertilization (IVF) cycle for unexplained infertility. Couples will be randomized to sperm selection by the clinical standard of centrifugation and density-gradient processing compared to the microfluidic sperm sorting chip.