Melanoma Clinical Trial
Official title:
Phase I Trial of Dacarbazine and Bortezomib in Melanoma and Soft Tissue Sarcoma
Bortezomib will enhance the activity of dacarbazine against melanoma and soft tissue sarcoma. Weekly administration of the combination will prove to be feasible and tolerable at an appropriate dose.
The primary objective is to determine recommended phase II doses for the combination
dacarbazine and bortezomib administered weekly.
Secondary objectives are to determine the maximum tolerated dose combination and to observe
anti-tumor activity in terms of response rate(s), duration of response, time to progression,
and time on treatment (a measure of both antitumor activity and treatment tolerance).
;
Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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