Snake Bites Clinical Trial
— LATOfficial title:
Comparing Modified Lee White Method Against 20 Minute Whole Blood Clotting Test as a Bedside Coagulation Test in Snake Envenomation Victims
Verified date | August 2020 |
Source | Jubilee Mission Medical College and Research Institute |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
20 minute Whole Blood Clotting Test(20'WBCT) recommended by World Health Organisation
guidelines is probably the most routinely employed bed side screening tool in the country.
The Modified Lee and White (MLW) method gives a value which when performed serially gives a
trend in clotting time which the investigators hypothesise to be a better tool in serially
assessing the victim compared to the 20'WBCT.
The investigators propose that delayed reading of both MLW and 20'WBCT to check for clot
stability at 30 minutes also provides added information in management of snake bite victims.
Status | Completed |
Enrollment | 230 |
Est. completion date | June 30, 2020 |
Est. primary completion date | May 31, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: 1. All victims of snake bite presenting to the emergency department AND 2. Consenting to be part of the study Exclusion Criteria: 1. Those not providing a written informed consent OR 2. Those on anticoagulants or antiplatelets OR 3. With a known hematological disorder OR 4. A known history of chronic liver disease OR 5. Received antivenom or blood products following snakebite at another centre |
Country | Name | City | State |
---|---|---|---|
India | Jubilee Mission Medical College and Research Institute | Thrissur | Kerala |
Lead Sponsor | Collaborator |
---|---|
Appu Suseel |
India,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Sensitivity and specificity of serial Modified Lee White Method(MLW) in comparison with twenty minute Whole Blood Clotting Test in detecting coagulopathy in snakebite victims. | 48 hours of snakebite | ||
Primary | Sensitivity and Specificity of admission Modified Lee White Method(MLW) and twenty minute Whole Blood Clotting Test in detecting coagulopathy in snakebite victims. | Comparing MLW and 20'WBCT to gold standard tests like Prothrombin Time (PT) and activated partial thromboplastin time (aPTT) | 48 hours | |
Secondary | Sensitivity of admission 20'WBCT and MLW to diagnose Russells viper (Daboia ruselli) envenomation | 48hours | ||
Secondary | Sensitivity of admission 20'WBCT and MLW to diagnose Hump-nosed pit viper (Hypnale hypnale) envenomation | 48hours | ||
Secondary | Time to detection of hematotoxic envenomation in MLW and 20'WBCT | 48 hours | ||
Secondary | Sensitivity and specificity of delayed reading of clotting time and clotting test at 30 minutes in detecting coagulopathy | 48 hours |
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