Smoking Clinical Trial
Official title:
Systematic Assessment of Response to Open-label Treatment With Varenicline in Depressed Outpatient Smokers
This study will assess whether varenicline (chantix) has antidepressant properties when used
in addition to other psychiatric medication. It will also assess whether varenicline improves
the inability to feel pleasure (i.e. anhedonia), and if it is well-tolerated when used with
psychiatric medications.
Enrolled patients will be assessed for improved mood, improved anhedonia, overall sense of
health, side effects as well as tobacco use for 6-8 weeks.
Medication will be provided free of charge.
Outpatient smokers who are depressed despite current stable psychiatric medication regimens
will be invited to participate.
They will receive varenicline dosed according to FDA-approved smoking cessation regime;
patients will be assessed using QIDS-SR16, snaith-hamilton anhedonia rating scale, SAFTEE and
clinical global improvement self-report scales and clinician global improvement scales at the
above time intervals.
Concurrent medication, psychiatric and non-psychiatric, will be recorded, as will vital signs
(BP, HR, weight) and tobacco use.
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