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Smoking clinical trials

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NCT ID: NCT02596061 Completed - Smoking Clinical Trials

In It To Quit: Commitment Contracts for Smoking Cessation

I2Q
Start date: November 2015
Phase: N/A
Study type: Interventional

This study aims to examine whether a combination of positive and negative commitment devices is effective at inducing long-term smoking cessation in smokers from a low-to-moderate income background. Investigators will randomly assign patients of a multi-site clinic in Connecticut to receive one or both of a succession of two commitment contracts. First, a two-month reward contract will pay participants for (a) engaging in clinic and web-based activities that support smoking cessation and (b) quitting smoking, as measured at period end. Second, a four-month deposit contract will invite participants to commit funds which they forfeit unless they abstain from smoking over the entire period. A random subset of participants will also have the option to pre-commit to the deposit contract at study enrollment. Reward payout and deposit recovery will be conditional on biochemical verification of self-reported abstinence. Investigators will conduct follow-up biochemical verification at 12 months to observe whether abstinence persists after removal of incentives. The primary outcome of interest will be continuous abstinence from smoking between months 2 and 12, i.e. biochemically verified abstinence at all three measurements. A short baseline and endline survey will also be administered to measure characteristics and outcomes related to smoking behavior.

NCT ID: NCT02591238 Completed - Smoking Clinical Trials

Melatonin in Smoke-induced Vascular Injury

Start date: June 2015
Phase: Phase 4
Study type: Interventional

The main purpose of this study was to evaluate the effects of melatonin in the regulation of the vascular injury in smokers through population-based, randomized, double-blind, placebo-controlled trial.

NCT ID: NCT02590640 Completed - Smoking Clinical Trials

Insular Inhibitory Neuromodulation to Reduce Cigarette Craving and Alter Brain Function in Smokers

Start date: November 2015
Phase: N/A
Study type: Interventional

The goal of this study is to determine if a specific experimental brain stimulation technique can be used as a non-invasive way to reduce cigarette cravings in current smokers. This study plans to learn more about the way an experimental technique called "transcranial magnetic stimulation" (TMS) affects a specific part of the brain, called the insula. Some research suggests that this part of the brain plays an important role in craving. The investigators plan to study the effects of TMS using standard surveys and magnetic resonance imaging (MRI) of subjects' brain. For interested participants, this study requires a single 3 hour appointment, which will include MRI of the brain as well as TMS.

NCT ID: NCT02565381 Completed - Smoking Clinical Trials

A Pilot Randomized Controlled Trial of Financial Incentives, Text Messaging, and Usual Care for Homeless Smokers

QUIT
Start date: October 2015
Phase: N/A
Study type: Interventional

The QUIT (Quitting with Usual Care, Incentives, and Technology) Smoking Study is a 3-arm pilot randomized controlled trial that will test the effect of 2 different experimental smoking cessation interventions relative to a control condition in homeless cigarette smokers. All participants will receive free transdermal nicotine patches and weekly in-person smoking cessation counseling. In addition, participants randomized to the first experimental condition will receive financial rewards for biochemically-verified smoking abstinence, and participants randomized to the second experimental condition will be enrolled in a text messaging program to support smoking abstinence.

NCT ID: NCT02539264 Completed - Obesity Clinical Trials

Impact of Smoking, Benzodiazepine (BZD) Use and Obesity on Severe Obstructive Sleep Apnea (sOSA)

Start date: January 2014
Phase: N/A
Study type: Observational

In this study the investigators will analyze the influence of smoking, benzodizepine use, and obesity among patients with severe Obstructive Sleep Apnea (sOSA).

NCT ID: NCT02532374 Completed - Smoking Clinical Trials

Nicotine Pharmacokinetic and Pharmacodynamics Profile, Safety and Tolerability of P3L

Start date: October 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD, i.e., subjective effects) profiles, and the safety and tolerability of the nicotine-containing aerosol delivered by Platform 3 Liquid (P3L) system at three different nicotine levels in smoking healthy subjects in relation to Nicorette® inhalator.

NCT ID: NCT02527980 Completed - Smoking Clinical Trials

E-Cigarettes: Dynamic Patterns of Use and Health Effects

Start date: October 1, 2015
Phase:
Study type: Observational

The proposed research will provide in-depth, longitudinal data, based on real-time reports, which will address key priorities for the FDA including, increased understanding of the relations between electronic cigarette (e-cig) use and 1) nicotine dependence, 2) reductions in combustible cigarette (CC) use, 3) attempts to quit CC use and the success of those attempts, and 4) health-related outcomes such as biomarkers of exposure and carcinogenicity.

NCT ID: NCT02521701 Completed - Smoking Clinical Trials

Safety and Efficacity of NFL101 as Tobacco Therapy

CESTO
Start date: December 2014
Phase: Phase 1
Study type: Interventional

This Phase I study is to investigate the safety of two dose levels of NFL-101 in smokers.

NCT ID: NCT02513069 Completed - Smoking Clinical Trials

Mobile Contingency Management for Smoking Cessation in Returning US Veterans

Start date: January 2015
Phase: N/A
Study type: Interventional

The primary goal of the study is to evaluate the effectiveness of a combined tele-health and contingency management (CM) intervention that the investigators call mobile CM, or mCM, in promoting smoking abstinence in US Veterans. The mCM intervention will combine a mobile system to reward non-smoking, smoking cessation counseling, and smoking cessation medications. The primary aim is to evaluate how effective this intervention is in promoting smoking abstinence compared to telehealth interventions for smoking cessation.

NCT ID: NCT02506829 Completed - Smoking Clinical Trials

Financial Incentives for Smoking Treatment

FIESTA
Start date: July 2015
Phase: N/A
Study type: Interventional

The investigators plan to compare the impact of two approaches for smoking cessation on smoking abstinence, use of evidenced-based therapy, and quality of life among a diverse population of patients at the Manhattan campus of the VA New York Harbor Healthcare System, which serves a critical safety-net role for urban veterans. During hospitalization, all smokers will receive usual care. Patients will be randomized to one of two arms: financial incentives plus usual care vs. usual care alone, which includes referral to the state Quitline. All patients enrolled in the study will be offered nicotine replacement therapy. The investigators will conduct follow-up assessments at 2 weeks, 2 months, 6 months and 12 months after discharge. The primary study outcome is smoking abstinence at 6-month follow-up, verified by salivary/urinary cotinine.