Coriandrum Sativum Seeds Improve Memory, Alleviate Anxiety and Depression, and Enhance Sleep Quality in University Students: A Randomized Controlled Trial

Sleep Clinical Trial

Official title:

Coriandrum Sativum Seeds Improve Memory, Alleviate Anxiety and Depression, and Enhance Sleep Quality in University Students: A Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05999071
• Other study ID #: 21/6/2022/2023
• Status: Completed
• Phase: N/A
• Start date: March 1, 2022
• Est. completion date: July 1, 2022

Study information

• Verified date: August 2023
• Source: The Hashemite University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

C. sativum could potentially serve as a memory enhancer for university students. It is considered a preferable option to stimulant drugs due to its safety profile. Additionally, C. sativum may have positive effects on anxiety, depression, and sleep quality. However, it is important to note that the current body of research on the effects of oral C. sativum on the brain and nervous system is limited, and further studies are necessary to fully understand its potential benefits. Thus, this study aims to assess the impact of oral C. sativum on memory performance, anxiety, depression, and sleep quality in university students.

Description:

Coriander, scientifically known as Coriandrum sativum L (C. sativum), is an ancient herb that belongs to the Apiaceae family. It has a rich history of more than 3,000 years of use in both culinary and medicinal practices. While originally native to Mediterranean regions, coriander is now cultivated in various countries worldwide. In traditional medicine, all parts of the coriander plant have been consumed and utilized to address gastrointestinal ailments like anorexia, dyspepsia, flatulence, diarrhea, pain, and vomiting. In Jordanian traditional medicine, C. sativum has been valued for its anticonvulsant, antidepressant, sedative, and anxiolytic properties. Studies have reported diverse health benefits associated with C. sativum seeds and leaves, including antioxidant, diuretic, cholesterol-lowering, anxiolytic, sedative-hypnotic, and anticonvulsant activities. Notably, the main component of C. sativum, linalool, along with γ-terpinene and α-pinene, exhibit various neuropharmacological effects, such as anti-anxiety, sedative, anticonvulsant, and anti-Alzheimer's disease properties. Additionally, C. sativum seeds are recognized as a valuable source of vitamins, lipids, and minerals like potassium, calcium, phosphorus, magnesium, sodium, and zinc.

Several studies have indicated the positive effects of C. sativum on memory, anxiety, and depression. In a specific study, the aqueous extract derived from the seeds of C. sativum demonstrated significant reductions in monoamine oxidase-B (MAO-B) activity over time, suggesting its primary role in exerting antidepressant-like effects. Another study reported that the administration of C. sativum leaves improved memory performance and hindered the aging process in rats in a dose-dependent manner. Furthermore, it was observed that C. sativum leaves reversed memory impairments induced by scopolamine and diazepam, while also significantly reducing brain cholinesterase activity and serum total cholesterol levels. Another study evaluated the effects of the ethanolic extract of C. sativum seeds on learning in second-generation mice. Although the plant extract did not enhance learning in the short term following training, it did show improvements in long-term learning. Additionally, in an animal model of anxiety, the effects of different doses (10 mg/kg, 25 mg/kg, 50 mg/kg, and 100 mg/kg administered intraperitoneally) of the aqueous extract of C. sativum seeds were evaluated in terms of motor activity and neuromuscular function. In the elevated plus-maze test, the 100 mg/kg dose of the seeds' aqueous extract exhibited anxiolytic effects by increasing the time spent in and the number of entries into the open arms.

Anxiety, depression, and sleep disorders are prevalent among university students, and these conditions can have a considerable impact on their memory function. Consequently, there has been a rise in the use of stimulant drugs among university students as a means to enhance memory performance and attention, despite the fact that such use is unapproved and non-therapeutic which might be associated with several side effects. As a result, there is a growing interest among neuroscience researchers to identify cognitive-enhancing drugs that can be safely used by healthy individuals without adverse effects.

Given the information provided, it is suggested that C. sativum could potentially serve as a memory enhancer for university students. It is considered a preferable option to stimulant drugs due to its safety profile. Additionally, C. sativum may have positive effects on anxiety, depression, and sleep quality. However, it is important to note that the current body of research on the effects of oral C. sativum on the brain and nervous system is limited, and further studies are necessary to fully understand its potential benefits. Thus, this study aims to assess the impact of oral C. sativum on memory performance, anxiety, depression, and sleep quality in university students.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 86
• Est. completion date: July 1, 2022
• Est. primary completion date: July 1, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 19 Years to 23 Years

Eligibility

Inclusion Criteria:

• Male or female university Student.

• 19-23 of age

Exclusion Criteria:

• Medical diseases.

• Psychiatric disorders.

• Using any form of medication (including complementary and alternative medicines).

• Pregnant and lactating individuals.

Related Conditions & MeSH terms

• Anxiety Depression
• Anxiety Disorders
• Depression
• Depressive Disorder
• Memory Disorders
• Sleep

Intervention

Dietary Supplement:
• Coriandrum sativum seeds
Each group consisted of 50 students. In the C. sativum group, dried powdered seeds of C. sativum were administered, while in the control group, starch was provided as a placebo. Both the C. sativum and placebo capsules were identical in shape, color, and outer packaging to maintain the blinding of the participants.

Locations

Country	Name	City	State
Jordan	Faculty of Pharmaceutical Sciences	Zarqa

Sponsors (1)

Lead Sponsor	Collaborator
The Hashemite University

Country where clinical trial is conducted

Jordan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Memory performance	Prospective and Retrospective Memory Questionnaire was performed	30 days
Secondary	Anxiety and depression	Hospital Anxiety and Depression Scale was perfomed	30 days
Secondary	Sleep quality	Pittsburgh Sleep Quality Inventory questionnaire was perfoemed	30 days