Depression Clinical Trial
Official title:
Circadian Sleep-wake Cycles, Well-being and Light Therapy in Borderline Personality Disorder
Individuals with borderline personality disorder (BPD) frequently suffer from emotional
instability, daytime fatigue and sleep disturbances. The investigators examined circadian
rhythms, sleep and well-being in women with BPD under their habitual life conditions with
and without light treatment.
Treated women diagnosed with BPD were investigated during 3 weeks without and 3 weeks with
morning LT. Rest-activity cycles were continuously measured using wrist actigraphy, together
with proximal skin temperature. Saliva samples were collected weekly to determine the
diurnal melatonin rhythm. A range of self-ratings and questionnaires were used to assess
depression and clinical state throughout the 6-week protocol. Ten matched healthy women
followed the same 6-week protocol without light treatment.
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