Sleep Disturbance Clinical Trial
— BioVibOfficial title:
Effects of Railway Vibration on Sleep and Disease
This study will investigate the biological mechanisms linking sleep disruption by vibration and noise, and the development of cardiometabolic disease. In a laboratory sleep study, the investigators will play railway vibration of different levels during the night. The investigators will also measure objective sleep quality and quantity, cognitive performance across multiple domains, self-reported sleep and wellbeing outcomes, and blood samples. Blood samples will be analyzed to identify metabolic changes and indicators of diabetes risk in different nights. Identifying biomarkers that are impacted by sleep fragmentation will establish the currently unclear pathways by which railway vibration exposure at night can lead to the development of diseases in the long term, especially metabolic disorders including diabetes.
Status | Recruiting |
Enrollment | 24 |
Est. completion date | December 31, 2024 |
Est. primary completion date | June 30, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 30 Years |
Eligibility | Inclusion Criteria: 1) live in or around the city of Gothenburg area (Sweden) Exclusion Criteria: 1. aged <18 or >30 years; 2. habitual sleep and wake timings more than ±1 hour different from the study sleep times (i.e. habitual sleep time should be 22:00-00:00 and habitual wake time should be 06:00-08:00); 3. BMI>25 kg/m2; 4. regular sleep medication use (prescribed or "over-the-counter"); 5. poor hearing acuity (measured during screening via pure tone audiometry); 6. diagnosed with sleep disorders; 7. diagnosed with diabetes 8. indications of sleep apnea on the STOP-BANG questionnaire; 9. shift work; 10. smoking, vaping, snus, or other nicotine use; 11. pregnant or breastfeeding |
Country | Name | City | State |
---|---|---|---|
Sweden | University of Gothenburg | Gothenburg | Västra Götaland |
Lead Sponsor | Collaborator |
---|---|
Göteborg University | University of Manitoba, University of Pennsylvania |
Sweden,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Fasting insulin resistance in the morning immediately after the Control night | Calculated using the Homeostatic model of insulin resistance (HOMA-IR) | One night | |
Primary | Fasting insulin resistance in the morning immediately after the low vibration night | Calculated using the Homeostatic model of insulin resistance (HOMA-IR) | One night | |
Primary | Fasting insulin resistance in the morning immediately after the intermediate vibration night | Calculated using the Homeostatic model of insulin resistance (HOMA-IR) | One night | |
Primary | Fasting insulin resistance in the morning immediately after the high vibration night | Calculated using the Homeostatic model of insulin resistance (HOMA-IR) | One night | |
Primary | Total sleep time during the Control night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total sleep time during the low vibration night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total sleep time during the intermediate vibration night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total sleep time during the high vibration night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total amount of N1 sleep during the Control night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total amount of N2 sleep during the Control night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total amount of N3 sleep during the Control night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total amount of rapid eye movement (REM) sleep during the Control night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total amount of N1 sleep during the low vibration night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total amount of N2 sleep during the low vibration night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total amount of N3 sleep during the low vibration night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total amount of rapid eye movement (REM) sleep during the low vibration night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total amount of N1 sleep during the intermediate vibration night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total amount of N2 sleep during the intermediate vibration night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total amount of N3 sleep during the intermediate vibration night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total amount of rapid eye movement (REM) sleep during the intermediate vibration night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total amount of N1 sleep during the high vibration night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total amount of N2 sleep during the high vibration night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total amount of N3 sleep during the high vibration night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Total amount of rapid eye movement (REM) sleep during the high vibration night | Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines | One night | |
Primary | Wakefulness after sleep onset (WASO) during the Control night | Total number of minutes awake during the night after the first appearance of sleep of any stage. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines. | One night | |
Primary | Wakefulness after sleep onset (WASO) during the low vibration night | Total number of minutes awake during the night after the first appearance of sleep of any stage. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines. | One night | |
Primary | Wakefulness after sleep onset (WASO) during the intermediate night | Total number of minutes awake during the night after the first appearance of sleep of any stage. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines. | One night | |
Primary | Wakefulness after sleep onset (WASO) during the high vibration night | Total number of minutes awake during the night after the first appearance of sleep of any stage. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines. | One night | |
Primary | Number of awakenings during the Control night | Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines. | One night | |
Primary | Number of awakenings during exposure to low vibration | Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines. | One night | |
Primary | Number of awakenings during exposure to intermediate vibration | Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines. | One night | |
Primary | Number of awakenings during exposure to high vibration | Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines. | One night | |
Primary | Sleep onset latency (SOL) during the Control Night | Defined as the time from lights out to the first epoch of sleep. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines. | One night | |
Primary | Sleep onset latency (SOL) during the low vibration night | Defined as the time from lights out to the first epoch of sleep. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines. | One night | |
Primary | Sleep onset latency (SOL) during the intermediate vibration night | Defined as the time from lights out to the first epoch of sleep. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines. | One night | |
Primary | Sleep onset latency (SOL) during the high vibration night | Defined as the time from lights out to the first epoch of sleep. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines. | One night | |
Primary | Sleep efficiency during the Control night | Defined as the percentage of time in bed spent in a non-wake sleep stage, measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines. | One night | |
Primary | Sleep efficiency during the low vibration night | Defined as the percentage of time in bed spent in a non-wake sleep stage, measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines. | One night | |
Primary | Sleep efficiency during the intermediate vibration night | Defined as the percentage of time in bed spent in a non-wake sleep stage, measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines. | One night | |
Primary | S Sleep efficiency during the high vibration night | Defined as the percentage of time in bed spent in a non-wake sleep stage, measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines. | One night | |
Primary | Sleep depth assessed using the odds ratio product (ORP) during the Control night | Average ORP over the full night, from 0 (never occurs during wake) to 2.5 (only occurs during wake). Derived via polysomnography/EEG measurements. | One night | |
Primary | Sleep depth assessed using the odds ratio product (ORP) during the low vibration night | Average ORP over the full night, from 0 (never occurs during wake) to 2.5 (only occurs during wake). Derived via polysomnography/EEG measurements. | One night | |
Primary | Sleep depth assessed using the odds ratio product (ORP) during the intermediate vibration night | Average ORP over the full night, from 0 (never occurs during wake) to 2.5 (only occurs during wake). Derived via polysomnography/EEG measurements. | One night | |
Primary | Sleep depth assessed using the odds ratio product (ORP) during the high vibration night | Average ORP over the full night, from 0 (never occurs during wake) to 2.5 (only occurs during wake). Derived via polysomnography/EEG measurements. | One night | |
Primary | Maximal change of odds ratio product (ORP) during exposure to railway vibration events | Measure of acute sleep disruption by noise, calculated as the difference between the ORP in the 30s prior to noise onset and the maximum ORP during railway vibration. Averaged over 36 vibration events during the night. | One night | |
Primary | Area under the curve of odds ratio product (ORP) during exposure to railway vibration events, calculated using the trapezoid rule | Measure of acute sleep disruption by noise, calculated as the difference between the ORP in the 30s prior to noise onset and the maximum ORP during railway vibration. Averaged over 36 vibration events during the night. | One night | |
Primary | N-acetylglucosamine/galactosamine (GlycA) concentration after the Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | N-acetylglucosamine/galactosamine (GlycA) concentration after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | N-acetylglucosamine/galactosamine (GlycA) concentration after exposure to intermediate vibration | Determined from NMR analysis of blood plasma | One night | |
Primary | N-acetylglucosamine/galactosamine (GlycA) concentration after exposure to high vibration | Determined from NMR analysis of blood plasma | One night | |
Primary | Sialic acid (GlycB) concentration after the Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Sialic acid (GlycB) concentration after exposure to low vibration | Determined from NMR analysis of blood plasma | One night | |
Primary | Sialic acid (GlycB) concentration after exposure to intermediate vibration | Determined from NMR analysis of blood plasma | One night | |
Primary | Sialic acid (GlycB) concentration after exposure to high vibration | Determined from NMR analysis of blood plasma | One night | |
Primary | Supramolecular phospholipid composite (SPC) concentration after the Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Supramolecular phospholipid composite (SPC) concentration after exposure to low vibration | Determined from NMR analysis of blood plasma | One night | |
Primary | Supramolecular phospholipid composite (SPC) concentration after exposure to intermediate vibration | Determined from NMR analysis of blood plasma | One night | |
Primary | Supramolecular phospholipid composite (SPC) concentration after exposure to high vibration | Determined from NMR analysis of blood plasma | One night | |
Primary | Ethanol concentration (mmol/L) after the Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Ethanol concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Ethanol concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Ethanol concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Trimethylamine-N-oxide concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Trimethylamine-N-oxide concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Trimethylamine-N-oxide concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Trimethylamine-N-oxide concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | 2-Aminobutyric acid concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One | |
Primary | 2-Aminobutyric acid concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One | |
Primary | 2-Aminobutyric acid concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One | |
Primary | 2-Aminobutyric acid concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One | |
Primary | Alanine concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Alanine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Alanine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Alanine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Asparagine concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Asparagine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Asparagine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Asparagine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Creatine concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Creatine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Creatine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Creatine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Creatinine concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Creatinine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Creatinine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Creatinine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glutamic acid concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glutamic acid concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glutamic acid concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glutamic acid concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glutamine concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glutamine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glutamine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glutamine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glycine concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glycine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glycine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glycine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Histidine concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Histidine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Histidine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Histidine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Isoleucine concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Isoleucine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Isoleucine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Isoleucine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Leucine concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Leucine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Leucine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Leucine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Lysine concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Lysine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Lysine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Lysine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Methionine concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Methionine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Methionine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Methionine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | N,N-Dimethylglycine concentration (mmol/L) after Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | N,N-Dimethylglycine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | N,N-Dimethylglycine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | N,N-Dimethylglycine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Ornithine concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Ornithine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Ornithine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Ornithine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Phenylalanine concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Phenylalanine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Phenylalanine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Phenylalanine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Proline concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Proline concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Proline concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Proline concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Sarcosine concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Sarcosine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Sarcosine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Sarcosine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Threonine concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Threonine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Threonine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Threonine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Tyrosine concentration (mmol/L) after exposure toControl night | Determined from NMR analysis of blood plasma | One night | |
Primary | Tyrosine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Tyrosine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Tyrosine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Valine concentration (mmol/L) after Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Valine concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Valine concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Valine concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | 2-Hydroxybutyric acid concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | 2-Hydroxybutyric acid concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | 2-Hydroxybutyric acid concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | 2-Hydroxybutyric acid concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Acetic acid concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Acetic acid concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Acetic acid concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Acetic acid concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Citric acid concentration (mmol/L) after Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Citric acid concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Citric acid concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Citric acid concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Formic acid concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Formic acid concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Formic acid concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Formic acid concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Lactic acid concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Lactic acid concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Lactic acid concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Lactic acid concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Succinic acid concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Succinic acid concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Succinic acid concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Succinic acid concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Choline concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Choline concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Choline concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Choline concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | 2-Oxoglutaric acid concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | 2-Oxoglutaric acid concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | 2-Oxoglutaric acid concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | 2-Oxoglutaric acid concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | 3-Hydroxybutyric acid concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | 3-Hydroxybutyric acid concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | 3-Hydroxybutyric acid concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | 3-Hydroxybutyric acid concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Acetoacetic acid concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Acetoacetic acid concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Acetoacetic acid concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Acetoacetic acid concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Acetone concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Acetone concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Acetone concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Acetone concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Pyruvic acid concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Pyruvic acid concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Pyruvic acid concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Pyruvic acid concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | D-Galactose concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | D-Galactose concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | D-Galactose concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | D-Galactose concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glucose concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glucose concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glucose concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glucose concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glycerol concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glycerol concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glycerol concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Glycerol concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Dimethylsulfone concentration (mmol/L) after exposure to Control night | Determined from NMR analysis of blood plasma | One night | |
Primary | Dimethylsulfone concentration (mmol/L) after exposure to low vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Dimethylsulfone concentration (mmol/L) after exposure to intermediate vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Dimethylsulfone concentration (mmol/L) after exposure to high vibration night | Determined from NMR analysis of blood plasma | One night | |
Primary | Response to an oral glucose bolus, calculated as area under curve for glucose, in the morning after the control night | Area under the curve (AUC) calculated using the trapezoidal rule, from glucose samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus. | One night | |
Primary | Response to an oral glucose bolus, calculated as area under curve for glucose, in the morning after the low vibration night | Area under the curve (AUC) calculated using the trapezoidal rule, from glucose samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus. | One night | |
Primary | Response to an oral glucose bolus, calculated as area under curve for glucose, in the morning after the intermediate vibration night | Area under the curve (AUC) calculated using the trapezoidal rule, from glucose samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus. | One night | |
Primary | Response to an oral glucose bolus, calculated as area under curve for glucose, in the morning after the high vibration night | Area under the curve (AUC) calculated using the trapezoidal rule, from glucose samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus. | One night | |
Primary | Response to an oral glucose load calculated as area under curve for insulin, in the morning after the low vibration night | Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus | One night | |
Primary | Response to an oral glucose load calculated as area under curve for insulin, in the morning after the intermediate vibration night | Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus | One night | |
Primary | Response to an oral glucose load calculated as area under curve for insulin, in the morning after the high vibration night | Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus | One night | |
Primary | Early response to an oral glucose load calculated as area under curve for insulin, in the morning after the control night | Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20 and 30 minutes after the glucose bolus | One night | |
Primary | Early response to an oral glucose load calculated as area under curve for insulin, in the morning after the low vibration night | Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20 and 30 minutes after the glucose bolus | One night | |
Primary | Early response to an oral glucose load calculated as area under curve for insulin, in the morning after the intermediate vibration night | Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20 and 30 minutes after the glucose bolus | One night | |
Primary | Early response to an oral glucose load calculated as area under curve for insulin, in the morning after the high vibration night | Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20 and 30 minutes after the glucose bolus | One night | |
Primary | Glucose tolerance in the morning after exposure to low vibration, assessed as glucose concentration 120 minutes after a glucose bolus | Glucose concentrations determined from plasma samples with the Hexokinase/G-6-PDH method | One night | |
Primary | Glucose tolerance in the morning after exposure to intermediate vibration, assessed as glucose concentration 120 minutes after a glucose bolus | Glucose concentrations determined from plasma samples with the Hexokinase/G-6-PDH method | One night | |
Primary | Glucose tolerance in the morning after exposure to high vibration, assessed as glucose concentration 120 minutes after a glucose bolus | Glucose concentrations determined from plasma samples with the Hexokinase/G-6-PDH method | One night | |
Primary | Glucose tolerance in the morning after Control night, assessed as glucose concentration 120 minutes after a glucose bolus | Glucose concentrations determined from plasma samples with the Hexokinase/G-6-PDH method | One night | |
Primary | Stumvoll Insulin sensitivity Index in the morning after control | .226 - 0.0032 × BMI - 0.0000645 × I120 - 0.00375 × G90, where I120 and G90 represent insulin concentration 120 minutes after the glucose bolus, and glucose concentration 90 minutes after the glucose bolus, respectively. | One night | |
Primary | Stumvoll Insulin sensitivity Index in the morning after exposure to low vibration | .226 - 0.0032 × BMI - 0.0000645 × I120 - 0.00375 × G90, where I120 and G90 represent insulin concentration 120 minutes after the glucose bolus, and glucose concentration 90 minutes after the glucose bolus, respectively. | One night | |
Primary | Stumvoll Insulin sensitivity Index in the morning after exposure to intermediate vibration | .226 - 0.0032 × BMI - 0.0000645 × I120 - 0.00375 × G90, where I120 and G90 represent insulin concentration 120 minutes after the glucose bolus, and glucose concentration 90 minutes after the glucose bolus, respectively. | One night | |
Primary | Stumvoll Insulin sensitivity Index in the morning after exposure to high vibration | .226 - 0.0032 × BMI - 0.0000645 × I120 - 0.00375 × G90, where I120 and G90 represent insulin concentration 120 minutes after the glucose bolus, and glucose concentration 90 minutes after the glucose bolus, respectively. | One night | |
Primary | Matsuda insulin sensitivity index in the morning after control exposure | Calculated as 10,000/square root of [fasting glucose × fasting insulin] × [mean glucose × mean insulin during oral glucose tolerance test]) | One night | |
Primary | Matsuda insulin sensitivity index in the morning after exposure to low vibration | Calculated as 10,000/square root of [fasting glucose × fasting insulin] × [mean glucose × mean insulin during oral glucose tolerance test]) | One night | |
Primary | Matsuda insulin sensitivity index in the morning after exposure to intermediate vibration | Calculated as 10,000/square root of [fasting glucose × fasting insulin] × [mean glucose × mean insulin during oral glucose tolerance test]) | One night | |
Primary | Matsuda insulin sensitivity index in the morning after exposure to high vibration | Calculated as 10,000/square root of [fasting glucose × fasting insulin] × [mean glucose × mean insulin during oral glucose tolerance test]) | One night | |
Secondary | Evening subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to control | The scale is a 9-level verbal scale from 1 - "Extremely alert" (best outcome) to 9 - "Very sleepy. great effort to keep alert, fighting sleep" (worst outcome) | One night | |
Secondary | Evening subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to low vibration | The scale is a 9-level verbal scale from 1 - "Extremely alert" (best outcome) to 9 - "Very sleepy. great effort to keep alert, fighting sleep" (worst outcome) | One night | |
Secondary | Evening subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to intermediate vibration | The scale is a 9-level verbal scale from 1 - "Extremely alert" (best outcome) to 9 - "Very sleepy. great effort to keep alert, fighting sleep" (worst outcome) | One night | |
Secondary | Evening subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to high vibration | The scale is a 9-level verbal scale from 1 - "Extremely alert" (best outcome) to 9 - "Very sleepy. great effort to keep alert, fighting sleep" (worst outcome) | One night | |
Secondary | Morning subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to control | The scale is a 9-level verbal scale from 1 - "Extremely alert" (best outcome) to 9 - "Very sleepy. great effort to keep alert, fighting sleep" (worst outcome) | One night | |
Secondary | Morning subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to low vibration | The scale is a 9-level verbal scale from 1 - "Extremely alert" (best outcome) to 9 - "Very sleepy. great effort to keep alert, fighting sleep" (worst outcome) | One night | |
Secondary | Morning subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to intermediate vibration | The scale is a 9-level verbal scale from 1 - "Extremely alert" (best outcome) to 9 - "Very sleepy. great effort to keep alert, fighting sleep" (worst outcome) | One night | |
Secondary | Morning subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to high vibration | The scale is a 9-level verbal scale from 1 - "Extremely alert" (best outcome) to 9 - "Very sleepy. great effort to keep alert, fighting sleep" (worst outcome) | One night | |
Secondary | Self-reported sleep disturbance by vibration after control exposure | Assessed on a 0-10 numerical scale, from "Not at all" to "Extremely" | One night | |
Secondary | Self-reported sleep disturbance by vibration after exposure to low vibration | Assessed on a 0-10 numerical scale, from "Not at all" to "Extremely" | One night | |
Secondary | Self-reported sleep disturbance by vibration after exposure to intermediate vibration | Assessed on a 0-10 numerical scale, from "Not at all" to "Extremely" | One night | |
Secondary | Self-reported sleep disturbance by vibration after exposure to high vibration | Assessed on a 0-10 numerical scale, from "Not at all" to "Extremely" | One night | |
Secondary | Morning positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after control exposure | PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these. | One night. | |
Secondary | Morning positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to low vibration | PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these. | One night. | |
Secondary | Morning positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to intermediate vibration | PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these. | One night. | |
Secondary | Morning positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to high vibration | PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these. | One night. | |
Secondary | Morning negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after control exposure | PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these. | One night. | |
Secondary | Morning negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to low vibration | PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these. | One night. | |
Secondary | Morning negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to intermediate vibration | PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these. | One night. | |
Secondary | Morning negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to high vibration | PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these. | One night. | |
Secondary | Evening negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to control | PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these. | One night. | |
Secondary | Evening negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to low vibration | PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these. | One night. | |
Secondary | Evening negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to intermediate vibration | PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these. | One night. | |
Secondary | Evening negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to high vibration | PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these. | One night. | |
Secondary | Evening positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to control | PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these. | One night. | |
Secondary | Evening positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to low vibration | PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these. | One night. | |
Secondary | Evening positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to intermediate vibration | PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these. | One night. | |
Secondary | Evening positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to high vibration | PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these. | One night. | |
Secondary | Event-related cardiovascular activation in response to control | Change in heart rate (ECG) | One night | |
Secondary | Event-related cardiovascular activation in response to low vibration | Change in heart rate (ECG) | One night | |
Secondary | Event-related cardiovascular activation in response to intermediate vibration | Change in heart rate (ECG) | One night | |
Secondary | Event-related cardiovascular activation in response to high vibration | Change in heart rate (ECG) | One night | |
Secondary | Evening neurobehavioural speed | Average of one key speed indicator from each of 10 cognitive tests (motor praxis, visual object learning, fractal 2-back, abstract matching, line orientation, emotion recognition, matrix reasoning, digit symbol substitution, balloon analog risk, psychomotor vigilance) | One night | |
Secondary | Evening neurobehavioural accuracy | Average of one key accuracy indicator from each of 9 cognitive tests (motor praxis, visual object learning, fractal 2-back, abstract matching, line orientation, emotion recognition, matrix reasoning, digit symbol substitution, psychomotor vigilance) | One night |
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