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Esketamine Combined With Remimazolam on Postoperative Sleep Disturbance and Anxiety in Patients

Sleep Disturbance Clinical Trial

Official title:
Effect of Esketamine Combined With Remimazolam on Postoperative Sleep Disturbance and Anxiety in Patients Undergoing Gastroenteroscopies

Clinical Trial Summary

To explore the effects of esketamine combined with remimazolam on postoperative sleep disturbance and anxiety in surgical patients undergoing gastroenteroscopies

Clinical Trial Description

Postoperative sleep disturbance (PSD) occur in the form of sleep deprivation, circadian rhythm disturbance, and structural abnormalities, and have a high incidence in patients undergoing surgery. Postoperative sleep disorders can lead to postoperative delirium and cognitive dysfunction, aggravate postoperative acute pain, and delay postoperative recovery. Benzodiazepines have a certain sedative hypnotic anti-anxiety effect, and remimazolam as a new benzodiazepine, its sedative hypnotic anti-anxiety effect is worthy of further exploration.Esketamine is an NMDA receptor antagonist with analgesic and sedative effects, and is widely used in clinical treatment of refractory depression. For patients undergoing surgery, in addition to sedation and analgesia, whether the intraoperative use of esketamine has positive effects on postoperative sleep disturbance and anxiety is worth exploring. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06108830
Study type Interventional
Source Tianjin Medical University General Hospital
Contact Guolin Wang, MD
Phone +8615822855556
Email wangguolinghad@hotmail.com
Status Recruiting
Phase N/A
Start date December 1, 2023
Completion date June 10, 2024
View Details
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