Clinical Trials Logo
  1. Home
  2. Sleep Disturbance
  3. NCT04287062

Examining the Role of the Orexin System in Sleep and Stress in Persons With Opioid Use Disorder

Sleep Disturbance Clinical Trial

Official title:
Examining the Role of the Orexin System in Sleep and Stress in Persons With Opioid Use Disorder

Clinical Trial Summary

This study is designed to elucidate the role of the orexin neurotransmitter system in sleep disturbance and circadian rhythms of stress that might in turn influence relapse behaviors in persons on medication-assisted treatments (MAT) who are in early recovery from opioid use disorder (OUD). Briefly, the study will enroll recently abstinent OUD patients (N=200) maintained on either extended-release naltrexone (XR-NTX), buprenorphine, or methadone. Within each MAT group, participants will be randomized to either suvorexant or placebo. The study is expected to have a 20% treatment attrition rate which will result in N=160 completers in the entire study. Patients will be recruited from and treated at Ashley Addiction Treatment, Addiction Treatment Services at Johns Hopkins Bayview Medical Center, Man Alive, or community providers.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04287062
Study type Interventional
Source Johns Hopkins University
Contact Andrew S Huhn, PhD
Phone 410-550-1971
Email ahuhn1@jhu.edu
Status Recruiting
Phase Phase 2
Start date November 20, 2020
Completion date August 2024
View Details
See also
  Status Clinical Trial Phase
Completed NCT04959214 - The Effect Of Progressıve Relaxatıon Exercıses N/A
Recruiting NCT05820919 - Enhancing Sleep Quality for Nursing Home Residents With Dementia - R33 Phase N/A
Completed NCT05555186 - The Effects of Bright Light Therapy on Adolescent's Sleep Quality and Well-being N/A
Completed NCT05093465 - A Comparison of Two Behavioral Sleep Interventions Among College Students (ProjectTECH) N/A
Completed NCT03673397 - The Acute Effect of Aerobic Exercise on Sleep in Patients With Depression N/A
Recruiting NCT04368416 - Anxiety/Depression, Sleep and Alcohol in Elderly Anxiety/Depression, Sleep Disturbances and Alcohol Use Disorder in Elderly With Cognitive Complaints
Completed NCT04566822 - Calm Sleep Coaching N/A
Not yet recruiting NCT06406309 - Settling Down for Sleep in ADHD: The Impact of Sensory and Arousal Systems on Sleep in ADHD N/A
Recruiting NCT00860756 - Sleep Disturbance in Deployed Soldiers Phase 0
Recruiting NCT05699837 - Alpha Entrainment for Pain and Sleep (Extension) N/A
Completed NCT06108115 - Smartphone-Based Intervention for Sleep Disturbance in Individuals Recovering From Alcohol Use Disorder N/A
Completed NCT05511818 - Radicle Rest: A Study of Cannabinoids on Sleep and Health Outcomes N/A
Completed NCT04560595 - Remote Guided Caffeine Reduction N/A
Not yet recruiting NCT06104280 - Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment N/A
Enrolling by invitation NCT04290650 - Sleep Disturbances in Patients With Psychotic Symptoms (AkuSleep) N/A
Recruiting NCT04207502 - Integrating Systematic Data of Geriatric Medicine to Explore the Solution for Health Aging
Suspended NCT03908905 - Sleep Disturbances and Chronic Widespread Pain
Completed NCT03269760 - Multimodal Sleep Pathway for Shoulder Arthroplasty Phase 1
Completed NCT04990206 - Improving Sleep Health in Adults With Overweight or Obesity N/A
Completed NCT03112824 - Functional Assessment of Ashwagandaha Root Extract During Weight Loss N/A