Hypertension Clinical Trial
Official title:
The Study Was Approved by the Ethics Committee of Our Institution, Which is Accredited by the Office of Human Research Protection as an Institutional Review Board
Obstructive sleep apnea (OSA) is a highly prevalent chronic sleep disorder that affects 3%
to 7% in middle aged individuals and increases with age. OSA has been identified as the most
common secondary cause associated with resistant hypertension. There is evidence that
compared with older patients, the risk of hypertension in OSA patients may be particularly
pronounced in younger adult ones (less than 50 years).
Traditionally, cardiovascular risk stratification in hypertensive patients was based on the
average blood pressure (BP) measured in the clinic. Accumulated data has shown that
target-organ damage is related not only to 24-h mean intra-arterial BP, but also to BP
variability (BPV) in subjects with essential hypertension. Growing evidence demonstrated
that BPV has considerable prognostic value for all-cause mortality and cardiovascular
outcomes, independent of average BP. In addition, it has been found that hypoxia condition
in pneumoconiosis patients was closely associated with exaggerated BPV in ambulatory BP.
However, the selections of antihypertensive drugs remain yet not very clearly for
hypertensive patients combined with OSA.
Obstructive sleep apnea (OSA) is a highly prevalent chronic sleep disorder that affects 3%
to 7% in middle aged individuals and increases with age. It is considered an important
independent contributing factor for the development of hypertension, diabetes and heart
rhythm disorders. The prevalence of arterial hypertension has been reported to reach 50% of
patients with OSA. OSA has been identified as the most common secondary cause associated
with resistant hypertension. There is evidence that compared with older patients, the risk
of hypertension in OSA patients may be particularly pronounced in younger adult ones (less
than 50 years).
Traditionally, cardiovascular risk stratification in hypertensive patients was based on the
average blood pressure (BP) measured in the clinic. Accumulated data has shown that
target-organ damage is related not only to 24-h mean intra-arterial BP, but also to BP
variability (BPV) in subjects with essential hypertension. Growing evidence demonstrated
that BPV has considerable prognostic value for all-cause mortality and cardiovascular
outcomes, independent of average BP. In addition, it has been found that hypoxia condition
in pneumoconiosis patients was closely associated with exaggerated BPV in ambulatory BP.
However, the selections of antihypertensive drugs remain yet not very clearly for
hypertensive patients combined with OSA.
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