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Identification of Predictive Neuroinflammatory Biomarkers of Neuro-radiological Evolution in Severe Traumatic Brain Injury — ICON-TBI  

Severe Traumatic Brain Injury Clinical Trial

Official title:
Identification of Predictive Neuroinflammatory Biomarkers of Neuro-radiological Evolution in Severe Traumatic Brain Injury

Clinical Trial Summary

Tertiary lesions responsible of the neurological decline after severe traumatic brain injury (TBI) are partially due to a persistent neuro-inflammation directly modulated by inflammatory mediators during the acute phase and detectable by using both multimodal MRI imaging and biological biomarkers during the acute phase after traumatic brain injury.

The main objective is to identify if the level of IL-1beta in cerebrospinal fluid predict in a reliable and reproducible way, the neuro-radiological evolution evaluated by the comparison of a quantitative MRI performed in post-resuscitation and at one year (quantitative ΔIRM) in traumatic brain injuried patients.

The secondary objectives are:

- To understand the links between the acute and chronic neuro-inflammatory phase in a population of TBI,

- To explore the contribution of the adaptive immune response in the persistent activation of the immune response,

- To Examine the links between persistent neuroinflammation, clinical deterioration and neuroimaging,

- To establish a correlation between the pathology and the physio-pathology of TBI.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03659006
Study type Interventional
Source Assistance Publique - Hôpitaux de Paris
Contact Vincent Degos, PU-PH
Phone 01 42 16 37 61
Email vincent.degos@aphp.fr
Status Recruiting
Phase N/A
Start date October 15, 2018
Completion date July 30, 2020
View Details
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