Severe Sepsis With Septic Shock Clinical Trial
Official title:
Randomized Control Trial to Assessed the Impact of Low Dose Unfractionated Heparin Treatment on Inflammation in Severe Sepsis
Sepsis is a clinical syndrome which infection trigger systemic inflammatory response.
Uncontrolled inflammatory process leads to multiple organ dysfunction and cause early
mortality in severe sepsis. Unfractionated heparin is an anticoagulant that widely used
either for DVT prophylaxis or treatment of disseminated intravascular coagulation. Heparin
also have an anti-inflammatory effect through downregulates nuclear factor kappa B and tumor
necrosis factor alpha.
Aim of this study is to determine effects of low dose unfractionated heparin treatment on
inflammation in severe sepsis patient.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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