Severe Obesity Design as BMI > 35kg/m2 Clinical Trial
Official title:
PREOPTI-POOP: Preoxygenation Optimisation in Obese Patients: High-flow Nasal Cannula Oxygen Versus Non-invasive Ventilation : A Single-centre Randomized Controlled Study. "
Oro-tracheal intubation in operating room in obese patients with BMI > 35kg/m2 remains a critical event. The aim of this study is to determine whether Nasal High Flow Therapy by nasal cannula Optiflow® is more efficient than the BIPAP preoxygenation before orotracheal intubation after crash induction in obese patients
This study will be designed as followed : Patients will be randomized in 2 groups :
- Preoxygenation during 4 minutes with High Flow Nasal Cannula (60l/min FiO2 (fraction of
inspired oxygen) = 1) before orotracheal intubation after crash induction. The device
will be maintained in place throughout the intubation procedure in order to achieve
apnoeic oxygenation.
- Or Preoxygenation during 4 minutes with Bi-level Positive Airway Pressure (BIPAP) with
Expiratory Positive Airway Pressure (EPAP) + 5 cm H2O and Inspiratory Airway Positive
Airway Pressure (IPAP) + 15, meaning a 10cm H2O pressure support. The facial mask with
be removed after before crash induction enabling laryngoscopic vision.
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