Clinical Trials Logo
  1. Home
  2. Sepsis
  3. NCT04644302
  4. Details
NCT04644302 Clinical Trial

Circulatory Coherence in COVID-19 and Non-COVID-19 Patients With Sepsis

Sepsis Clinical Trial

Official title:
Circulatory and Endothelial Coherence in COVID-19 and Non-COVID-19 Patients With Sepsis - Prospective, Observational Pilot Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04644302
Other study ID # FNHK_IGS_8144
Secondary ID
Status Completed
Phase
First received
Last updated
Start date February 1, 2020
Est. completion date July 1, 2021

Study information
Verified date September 2021
Source University Hospital Hradec Kralove
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This prospective observational pilot study investigates circulatory coherence in patients with COVID and non-COVID sepsis by comparison of microcirculation, endothelial glycocalyx, and clinical course

Description:

This prospective observational pilot study investigates circulatory coherence in patients with COVID and non-COVID sepsis by comparison of microcirculation (sublingual area video recordings and biochemical parameters of endothelial cells activation and damage) endothelial glycocalyx (sublingual area video recordings and biochemical parameter of glycocalyx degradation), and clinical course.

Recruitment information / eligibility
Status Completed
Enrollment 28
Est. completion date July 1, 2021
Est. primary completion date July 1, 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - adult - ICU admission due to sepsis with organ failure - need for organ support therapy (mechanical ventilation, CRRT, ECMO) - clinical and/or laboratory signs of circulatory instability Exclusion Criteria: - family withdrawal/disagreement - death within three days from ICU admission

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• microcirculation recording
non-invasive recording of sublingual microcirculation and blood sampling together with regular withdraws

Locations
Country Name City State
Czechia University Hospital Hradec Kralove Hradec Králové Trebeš

Sponsors (1)
Lead Sponsor Collaborator
University Hospital Hradec Kralove

Country where clinical trial is conducted

Czechia, 

Outcome
Type Measure Description Time frame Safety issue
Primary change in Proportion of Perfused Vessels (PPV) parameter PPV describes microcirculation dysfunction 1st, 2nd and 3rd day
Primary change in Syndecan-1 serum concentration Syndecan-1 is a marker of endothelial glycocalyx 1st, 2nd and 3rd day
Secondary change in albuminuria albuminuria is a marker of glomerular endothelial cells dysfunction 1st, 2nd and 3rd day
Secondary mortality in 28 days mortality in 28 days from ICU admission 30 days
See also
  Status Clinical Trial Phase
Active, not recruiting NCT05095324 - The Biomarker Prediction Model of Septic Risk in Infected Patients
Completed NCT02714595 - Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens Phase 3
Completed NCT03644030 - Phase Angle, Lean Body Mass Index and Tissue Edema and Immediate Outcome of Cardiac Surgery Patients
Completed NCT02867267 - The Efficacy and Safety of Ta1 for Sepsis Phase 3
Completed NCT04804306 - Sepsis Post Market Clinical Utility Simple Endpoint Study - HUMC
Recruiting NCT05578196 - Fecal Microbial Transplantation in Critically Ill Patients With Severe Infections. N/A
Terminated NCT04117568 - The Role of Emergency Neutrophils and Glycans in Postoperative and Septic Patients
Completed NCT03550794 - Thiamine as a Renal Protective Agent in Septic Shock Phase 2
Completed NCT04332861 - Evaluation of Infection in Obstructing Urolithiasis
Completed NCT04227652 - Control of Fever in Septic Patients N/A
Enrolling by invitation NCT05052203 - Researching the Effects of Sepsis on Quality Of Life, Vitality, Epigenome and Gene Expression During RecoverY From Sepsis
Terminated NCT03335124 - The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock Phase 4
Recruiting NCT04005001 - Machine Learning Sepsis Alert Notification Using Clinical Data Phase 2
Completed NCT03258684 - Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock N/A
Recruiting NCT05217836 - Iron Metabolism Disorders in Patients With Sepsis or Septic Shock.
Completed NCT05018546 - Safety and Efficacy of Different Irrigation System in Retrograde Intrarenal Surgery N/A
Completed NCT03295825 - Heparin Binding Protein in Early Sepsis Diagnosis N/A
Not yet recruiting NCT06045130 - PUFAs in Preterm Infants
Not yet recruiting NCT05361135 - 18-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in S. Aureus Bacteraemia N/A
Not yet recruiting NCT05443854 - Impact of Aminoglycosides-based Antibiotics Combination and Protective Isolation on Outcomes in Critically-ill Neutropenic Patients With Sepsis: (Combination-Lock01) Phase 3