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NCT04203784 Clinical Trial

Meropenem and Piperacillin Plasma Concentrations During CRRT

Sepsis Clinical Trial

— ABC2  

Official title:
Meropenem and Piperacillin Plasma Concentrations During CRRT

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04203784
Other study ID # K 2019-9604
Secondary ID
Status Completed
Phase
First received
Last updated
Start date November 1, 2012
Est. completion date December 31, 2016

Study information
Verified date December 2019
Source Karolinska University Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This observational study reports meropenem and piperacillin plasma concentrations in patients treated with either antibiotic and simultaneous continuous renal replacement therapy (CRRT).

Recruitment information / eligibility
Status Completed
Enrollment 135
Est. completion date December 31, 2016
Est. primary completion date December 31, 2016
Accepts healthy volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- patients treated in the study ICU and

- simultaneous CRRT and antibiotic treatment with either meropenem or piperacillin-tazobactam.

Exclusion Criteria:

- none

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Plasma concentration measurements
Plasma concentration measurements

Locations
Country Name City State
Sweden Karolinska University Hospital Solna Stockholm

Sponsors (1)
Lead Sponsor Collaborator
Karolinska University Hospital

Country where clinical trial is conducted

Sweden, 

Outcome
Type Measure Description Time frame Safety issue
Primary Plasma antibiotic concentrations at mid and end of dosing interval We vill report the measured plasma antibiotic concentrations at the mid and end of the dosing interval. 1 week
Primary Plasma antibiotic concentrations at mid and end of dosing interval The percentage of patients having a concentration above the highest MIC (minimal inhibitory concentration) breakpoint for pathogens considered susceptible for the antibiotic. 1 week
Primary Relationships between plasma antibiotic concentrations and CRRT dose. We will report the correlation between measured plasma concentrations of either antibiotic and the intensity of the CRRT treatment. 1 week
Primary Influence of residual diuresis on the measured plasma antibiotic concentrations. We will report the correlation between measured plasma concentrations of either antibiotic and residual diuresis. 1 week
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