Sepsis Clinical Trial
Official title:
Possible Links Between Inflammation and Lipid Metabolism
Verified date | October 2018 |
Source | Barmherzige Brüder Linz |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
It has been recognized lately that sepsis and inflammation has an important impact on lipid metabolism and that the extent of hypocholesterolemia may even be a marker of severity of illness. However, the interplay between inflammation and the marked changes in lipid metabolism remain to be sufficiently understood. Importantly, the exact kinetics of lipid parameters in inflammatory conditions are yet to be explored. This study aims to investigate the interaction between inflammation and lipid metabolism using the human endotoxin model (LPS infusion) in ten healthy volunteers in a single blinded randomized placebo controlled cross-over design.
Status | Completed |
Enrollment | 10 |
Est. completion date | September 30, 2018 |
Est. primary completion date | July 30, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: - Men aged 18 to 40 years - Written informed consent - No disease history - non-smoker - BNP level within the normal range - Normal renal function (serum creatinine of 1.3 mg/dL and/or creatinine clearance greater than 80ml/min) Exclusion Criteria: - Systolic blood pressure < 90 mmHg - Subjects on any medication - History of anaphylaxis - Probands who suffer from infectious disease |
Country | Name | City | State |
---|---|---|---|
Austria | Barmherzige Brüder Linz - Innere Medizin | Linz |
Lead Sponsor | Collaborator |
---|---|
Barmherzige Brüder Linz |
Austria,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | lipid kinetics | levels of lipid parameters including LDL, HDL, lipoprotein(a), apolipoprotein A1 and apoB will be measured at multiple timepoints (t0, t15, t30, t60, t120, t180, t360, 24h and 48h) in order to evaluate the detaile kinetics of lipid parameters in inflammatory condidtions | 48 hours |
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