Sepsis Clinical Trial - Release of Nociceptin From Granulocytes in Sepsis

Status Completed

Clinical Trial Summary

Nociceptin is a protein found in the body, with a number of functions in the central nervous system, blood vessels and the gut. There is evidence that it may have a role in controlling the immune response to infection, and may act as a link between the brain and immune system. In infection, or after surgery, there is an increase in nociceptin, and subjects greater elevations of nociceptin have a poorer outcome. There is evidence that cells of the immune system may produce nociceptin, although it is not yet known which cells are capable of producing it, and what "switches on" production. This study aims to determine 1. Which cells of the immune system can produce nociceptin 2. If there is a difference in the ability to produce nociceptin between healthy volunteers and patients with severe infections

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Sepsis
Sepsis Syndrome
Septic Shock
Severe Sepsis
Systemic Inflammatory Response Syndrome
Toxemia

Clinical Trial Details

NCT number	NCT03037281
Study type	Observational
Source	University of Leicester
Contact
Status	Completed
Phase
Start date	April 7, 2016
Completion date	June 30, 2019

View Details

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