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Clinical Trial Summary

Nociceptin is a protein found in the body, with a number of functions in the central nervous system, blood vessels and the gut. There is evidence that it may have a role in controlling the immune response to infection, and may act as a link between the brain and immune system. In infection, or after surgery, there is an increase in nociceptin, and subjects greater elevations of nociceptin have a poorer outcome. There is evidence that cells of the immune system may produce nociceptin, although it is not yet known which cells are capable of producing it, and what "switches on" production. This study aims to determine 1. Which cells of the immune system can produce nociceptin 2. If there is a difference in the ability to produce nociceptin between healthy volunteers and patients with severe infections


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03037281
Study type Observational
Source University of Leicester
Contact
Status Completed
Phase
Start date April 7, 2016
Completion date June 30, 2019

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