Sepsis Clinical Trial
Official title:
Application of Vibration Therapy as a Measure of Muscle Activation in ICU Patients and Its Effect on Hemodynamics, Intracranial Pressure as Well as Energy Metabolism
Vibration therapy is used for different indications in rehabilitation and sports medicine.
So far, vibration therapy has not been investigated within the ICU setting. The
investigators created this setting to show safety and applicability of vibration therapy in
ICU patients. 30 patients will be stimulated by vibration therapy on two separate days
during their ICU stay. Three collectives of equal size will be observed: One with patients
on mechanical ventilation without signs of infection or suspected intracranial pressure
problems, a second one with patients on mechanical ventilation in addition to signs of
systemic inflammation but absence of suspected intracranial pressure problems, and a third
one with patients on mechanical ventilation, signs of systemic inflammation in addition to
presence of controlled intracranial pressure problems. Typical parameters of hemodynamic
status, intracranial pressure and energy metabolism will be recorded for a defined period of
time before, during and after vibration therapy itself. Vibration therapy will be combined
with protocol based physiotherapy.
Our aim is to show the effects of vibration therapy in ICU patients and its safe
applicability.
ADDITION 06th of May 2011: Additionally we will perform euglycaemic hyperinsulinemic clamp
and intervention on one day of ICU stay in 20 patients. Under clamp conditions we will
perform a vibration therapy (ProMedVi Vibrosphere™) on patients' legs. On top we will
perform electrical muscle stimulation (schwa-medico, MUSKELaktiv™) on one ventral upper leg,
randomized chosen. Measuring the local skeletal muscle metabolism will be done by
microdialysis in Vastus lateralis on both sides - comparing vibration therapy and vibration
therapy combined with electrical muscle stimulation.
n/a
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