Study of Antithrombotic Treatment After IntraCerebral Haemorrhage — STATICH  

Atrial Fibrillation Clinical Trial

Official title: Study of Antithrombotic Treatment After IntraCerebral Haemorrhage

Status Recruiting

Clinical Trial Summary

The study evaluates the effects of antithrombotic drugs (anticoagulant drugs or antiplatelet drugs) for prevention of ischaemic events in patients With recent intracerebral haemorrhage.

Clinical Trial Description

Patients with spontaneous ICH have an increased risk of recurrent ICH and they also have an increased risk of ischaemic diseases. Around 40-50% of patients use, or have an indication, for antithrombotic drugs at the time of ICH. However, little is known about the benefits and harms of using antithrombotic drugs for prevention of ischaemic events in patients who have had an ICH.

There are only observational studies addressing this question. Because of the lack of randomised-controlled trials and the inconclusive findings of the observational studies, guidelines have variably endorsed both starting and avoiding antithrombotic drugs after ICH.

The investigators therefore want to study the effect and safety of using antithrombotic drugs after ICH. Furthermore, since findings on MRI can be biomarkers for subsequent bleeding, there will also be performed a sub-study of the association between such findings on MRI and risk of recurrent ICH during treatment with antithrombotic drugs.

Patients with ICH during the last 6 months and with an indication for antithrombotic drugs will be included. Patients with vascular disease and indication for antiplatelet drugs will be randomised to antiplatelet treatment vs. no antithrombotic treatment. Patients with atrial fibrillation and indication for anticoagulant treatment will be randomised to anticoagulant treatment vs. no anticoagulant treatment. The follow up period is 2 years, and the primary effect variable is new ICH. The investigators will also assess new intracranial haemorrhage, extracranial haemorrhage and ischemic events, and functional and cognitive outcome. ;

Related Conditions & MeSH terms

• Anticoagulant-Induced Bleeding
• Atrial Fibrillation
• Cerebral Hemorrhage
• Hemorrhage
• Intracranial Hemorrhages
• Secondary Prevention

• NCT number: NCT03186729
• Study type: Interventional
• Source: Oslo University Hospital
• Contact: Torgeir Bruun Wyller, PhD
• Phone: 004791166682
• Email: t.b.wyller@medisin.uio.no
• Status: Recruiting
• Phase: Phase 4
• Start date: July 1, 2018
• Completion date: June 2031