Sequential Multiple Assignment Randomized Trial for Bipolar Depression
This is a sequential multiple assignment randomized trial for adults (ages > 18) with a bipolar disorder type 1 diagnosis currently experiencing a depressive episode. It is a randomized pragmatic trial that will compare four commonly prescribed treatments for bipolar depression, which includes three FDA-approved medications (Cariprazine, Quetiapine and Lurasidone) and one antipsychotic/antidepressant combination (Aripiprazole/Escitalopram).
NCT06433635 — Depression
Status: Not yet recruiting
http://inclinicaltrials.com/depression/NCT06433635/
Optimizing the Synergy Between Behavioural Activation Therapy and Esketamine for Resistant Depression
This is a randomized clinical trial to test the effectiveness of combining a proven psychological intervention called behavioural activation therapy alongside esketamine treatment for treatment resistant major depressive episodes in individuals with major depressive disorder or bipolar disorder. Encouraging participants to practice new behaviours while their mood is improved through esketamine treatment may lead to more lasting recovery from depression.
NCT06431386 — Bipolar Disorder
Status: Recruiting
http://inclinicaltrials.com/bipolar-disorder/NCT06431386/
Ecological Momentary Intervention (EMI) as Augmentative Therapy for Depression in Clinical Sample in Hong Kong
To determine if a two-week ecological momentary intervention (two EMA + one EMI daily) as augmentation to treatment as usual would reduce depressive symptoms, rumination levels, and functioning in subjects with mild to moderate depression, as compared to active controls receiving three EMA prompts daily.
NCT06430476 — Mild to Moderate Depression
Status: Recruiting
http://inclinicaltrials.com/mild-to-moderate-depression/NCT06430476/
Sleep to Reduce Incident Depression Effectively in Peripartum
Perinatal depression (PND) is the most common complication in pregnancy and postpartum, which increases risk for adverse perinatal outcomes such as preterm birth, maternal suicidal thoughts, and impaired mother-infant bonding. Insomnia often precedes PND cases and may serve as an entry point for interventions preventing PND. The proposed project is a large-scale clinical trial to test the effectiveness of a mindfulness-based sleep program designed for pregnant women to improve sleep and alleviate cognitive arousal to reduce risk for PND across pregnancy and postpartum.
NCT06430333 — Depression
Status: Not yet recruiting
http://inclinicaltrials.com/depression/NCT06430333/
Combining Treatment Components in Transdiagnostic Therapy for Anxiety and Depression: A Randomized Controlled Trial
The present study is a randomized controlled trial that will evaluate the effect of combining two treatment components (i.e., cognitive restructuring and detached mindfulness) drawn from cognitive behavioral therapies (CBTs) that are often combined in clinical practice. However, knowledge about the effect of combining these treatment components is lacking. Therefore, this study aims to explore single, combined, and sequencing effects of these two treatment components in patients with depression and/or anxiety disorders. Furthermore, the study aims to explore possible demographic and clinical moderators of the effects to address the question of what works for whom.
NCT06429956 — Depression
Status: Not yet recruiting
http://inclinicaltrials.com/depression/NCT06429956/
Based on the Theory of Gut-brain Axis, the Intervention Effect and Related Mechanism of Ganoderma Lucidum Spore Powder on Depressive Symptoms in Patients With Thyroid Cancer Were Investigated
To clarify the clinical effect of Ganoderma lucidum spore powder intervention on postoperative depressive symptoms of papillary thyroid carcinoma ; to elucidate the antidepressant mechanism of Ganoderma lucidum spore powder.
NCT06429514 — Depression
Status: Completed
http://inclinicaltrials.com/depression/NCT06429514/
Obsessive-compulsive Disorder, Depression and Anxiety Among Patients With Crohn's Disease
Introduction: Crohn's disease (CD) and obsessive-compulsive disorder (OCD) are two distinct medical conditions that affect millions of people worldwide. While numerous studies have explored anxiety and depression in CD, there is a notable lack of research about the link between OCD and CD. The aim of the study is to look for a relation between these seemingly unrelated conditions. Methods: Patients with a diagnosis of Crohn's disease were given four different questionnaires in order to assess for the presence of obsessive-compulsive disorder, depression, and anxiety symptoms using the OCI-R score, DASS-21, PHQ-9, and GAD-7. The same questionnaires were used to assess healthy controls for similar symptoms.
NCT06429488 — Inflammatory Bowel Diseases
Status: Completed
http://inclinicaltrials.com/inflammatory-bowel-diseases/NCT06429488/
Salivary Biomarkers of Gingival Inflammation Are Associated With Depression
The goal of this observational study is to evaluate the inflammatory saliva biomarkers in depression and gingivitis. The main question will be ; Will there be an increase at salivary biomarkers with depression patients and is it associated with gingivitis?
NCT06427902 — Depression
Status: Completed
http://inclinicaltrials.com/depression/NCT06427902/
Development and Feasibility of a Metaverse-based Blended Online Intervention to Prevent Employees' Depression: Applying Intervention Mapping
The goal of this feasibility study is to develop a new metaverse-based blended online intervention using an online program and coaching via metaverse to prevent depression among Generation MZ Employees in South Korea. In addition, this study primarily explores reach and acceptability and secondarily evaluates the preliminary effectiveness of this preventive intervention on Korea's Gen MZ Employees.
NCT06426342 — Depression and Suicide
Status: Not yet recruiting
http://inclinicaltrials.com/depression-and-suicide/NCT06426342/
Effect of Targeted Health Education Program on Nurses' Awareness About Postpartum Depression
To assess nurses' knowledge of PPD at Ain Shams University Maternity Hospital and measure their knowledge level after an educational program on postpartum depression.
NCT06424496 — Postpartum Depression
Status: Completed
http://inclinicaltrials.com/postpartum-depression/NCT06424496/