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Scar clinical trials

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NCT ID: NCT06437912 Completed - Scar Clinical Trials

Effectiveness of Botulinum Toxin A in Preventing Scar Formation and Initial Exploration of "Optimal Concentration"

Start date: March 23, 2023
Phase: Early Phase 1
Study type: Interventional

Each year, millions of burn, trauma, or surgical patients worldwide suffer from scarring that severely affects their quality of life and social functioning. In order to prevent and treat diseases related to abnormal scar hyperplasia, clinicians and researchers have adopted various methods, such as scar grinding, surgical resection, drug injection in scar tissue, cryotherapy, laser and so on. However, these methods can not effectively inhibit the abnormal proliferation of scars and improve the adverse effects of existing scars on patients. To date, there is no accepted gold standard for the effective treatment and improvement of abnormal scar tissue.

NCT ID: NCT06119113 Completed - Scar Clinical Trials

Wound Infection Due to Suture Material in Caesarean Skin Incision and Evaluation of Cosmetic Results

Start date: January 1, 2023
Phase: N/A
Study type: Interventional

Our primary aim is to determine the most beneficial suture in order to reduce complications due to skin incision in common surgeries such as cesarean section, and our secondary aim is to evaluate the suture material used in terms of cosmetic results and participant preference.

NCT ID: NCT05618912 Completed - Clinical trials for Patient Satisfaction

Scar Appearance After Postoperative Hydrocolloid Dressing Versus Standard Petrolatum Ointment

Start date: October 17, 2022
Phase: N/A
Study type: Interventional

Patients will be randomized either to receive standard daily dressing or hydrocolloid dressing using a randomization generator. After closing the wound with the sutures,the scar will be covered by a hydrocolloid dressing, which will be left in place for 7 days(Experimental) or the standard dressing (Control) that will be covered with petrolatum jelly and bandaging during this time period, which has to be re-applied daily. Patients and dermatologic surgeons will then complete surveys 7 days, 30 days, and 90 days after surgery to evaluate the cosmetic appearance of these scars.

NCT ID: NCT05527756 Completed - Scar Clinical Trials

Evaluation of the Cosmetic Outcomes of Totally Endoscopic Cardiac Surgery

SCARMICS
Start date: October 21, 2022
Phase:
Study type: Observational

Totally endoscopic cardiac surgery (TECS) is considered to have aesthetic advantages over conventional median sternotomy due to the smaller incisions. Most research regarding TECS focuses on clinical outcomes instead of cosmetic consequences. Following surgery, postoperative scarring is unavoidable and may negatively affect the patient's physical and emotional well-being. Therefore, this study aims to investigate the cosmesis after TECS.

NCT ID: NCT05293652 Completed - Scar Clinical Trials

Effect of Hydrocortisone Iontophoresis Versus Hydrocortisone Phonophoresis On Post Surgical Scar

Start date: September 1, 2021
Phase: N/A
Study type: Interventional

The purpose of this study will be to compare the effect of hydrocortisone iontophoresis and hydrocortisone phonophoresis on the treatment of surgical scar and overall scar appearance.

NCT ID: NCT05271708 Completed - Scar Clinical Trials

Explore the Short- and Mid-term Effects of Fespixon in Scar Cosmesis Following Cervical or Abdominal Surgery

Start date: January 5, 2022
Phase: Phase 4
Study type: Interventional

The aim of this study is to evaluate the efficacy of the Fespixon cream for prevention and/or appearance reduction of different types of linear scars during the 12-week treatment phase, which is assessed by the blinded independent evaluator.

NCT ID: NCT05149118 Completed - Scar Clinical Trials

Effect of PDRN in Post-operative Scars

Start date: February 1, 2019
Phase: Phase 4
Study type: Interventional

The investigators aimed to evaluate the efficacy of PDRN administration in early wound healing phase on prevention of post-operative scars after open thyroidectomy.

NCT ID: NCT04870008 Completed - Scar Clinical Trials

Aesthetic Outcome of Running Cuticular Suture Distance (2mm vs 5mm)

Start date: November 20, 2019
Phase: N/A
Study type: Interventional

It is standard teaching that the top layer of sutures should be placed 3-5mm from the wound edge. However, there is lack of data regarding the most optimal placement of sutures from the wound edge for the best cosmetic outcome. The research team wish to determine if sutures placed closer to the wound edge (2mm) or farther from the wound edge (5mm) makes a difference in the cosmetic outcome of the scar.

NCT ID: NCT04554316 Completed - Breast Neoplasms Clinical Trials

Aesthetic Effect of Steri-Strip Orientation on Healing and Scar Appearance in Breast Surgery

Start date: November 1, 2020
Phase: N/A
Study type: Interventional

All patients undergoing breast biopsy, lumpectomy, needle-localization-guided breast biopsy, and mastectomy at Einstein Medical Center Philadelphia, Einstein Medical Center Montgomery, Center One, or Einstein Elkins Park will be offered participation into the study. Patients who have documented allergies to adhesive or tape, patients taking chronic steroids, and patients with documented connective tissue, skin, or healing disorders will be excluded from the study. Risks and benefits of the study as well as risks and benefits of the procedure will be discussed with the patient by one of the investigators. If the patient elects to participate in the study, they will be assigned to incisional dressing at the time of operation with either in-line or perpendicular placement of Steri-Strips based on the patient's computer-generated randomization assignment. The patient's chart will be reviewed to determine the patient's age and comorbid conditions including obesity (pre-operative BMI), diabetes mellitus, use of anti-platelet or anticoagulant medication, or smoking. This information will be utilized to ensure that our study groups are similar in baseline demographics and pre-existing conditions. Additionally, the primary medical reason for needing breast surgery will be reviewed as well as treatment with pre-operative or post-operative chemotherapy or radiation therapy to the breast. Steri-Strips will not be removed and will be allowed to fall off naturally. At regularly scheduled 30-day and 90-day follow-up appointments, pictures will be taken of the incisional area. These photographs will be reviewed by a blinded, independent surgeon who will grade each incision according to the modified Hollander Cosmesis Scale. Statistical analysis with t-testing of the means and chi-squared testing of dichotomous variables will be performed to determine significance of the findings.

NCT ID: NCT04331080 Completed - Clinical trials for Breast Reconstruction

A Study of Granexin® Gel for the Reduction of Scar Formation in Surgical Wounds Following Bilateral Anchor Incision Breast Surgery

Start date: July 1, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to evaluate effectiveness of Granexin® gel in reducing scar formation in surgical incisional wounds.