Clinical Trials Logo

Clinical Trial Summary

The aim of this project is to investigate the reward responses to oral erythritol compared to sucrose and sucralose using flavor preference learning in healthy participants. In addition, the release of GI hormones, glycemic control, appetite-related sensations, and emotional state in response to erythritol will be investigated.


Clinical Trial Description

This trial is a randomized, double-blind, cross-over study; the project set-up will be single-centre, national. The study is composed of six visits: one screening visit, one pre-test visit, three conditioning visits, and one post-test visit. The screening and pre-test will last about two hours, the conditioning days and the post-test day about 4 hours each. During the screening participants take part in a 6-n-propylthiouracil (PROP) sensitivity test to exclude potential supertasters. Moreover, the participants will rate explicit liking and explicit wanting of 10 non-caloric flavored and colored beverages in a randomized order (flavor preference learning). The pre-test visit consists of two parts. First, a chemosensory sweetness matching will be performed, during which we will establish dose-response relationships for perceived sweetness of sucrose, erythritol, and sucralose using equisweet watery solutions across a range of concentrations. Second, the participants will perform a triangle test to ensure that they cannot distinguish the matched erythritol and sucralose solutions from a 10% sucrose solution. During the 3 conditioning visits, participants will be presented with three conditioning trials (at t = 0, 45, and 90min), each consisting of drinking 100mL of the flavored drink (CS) paired with one of the sweet substances (US = erythritol, sucrose, or sucralose). In post-test visit, preference for each of the 3 flavored CS drinks will be assessed and a computerized forced choice task will be completed by the participants. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05279183
Study type Interventional
Source University Hospital, Basel, Switzerland
Contact
Status Completed
Phase N/A
Start date March 17, 2022
Completion date September 16, 2022

See also
  Status Clinical Trial Phase
Completed NCT04219189 - The Acute Effect of Vaping on Food Intake N/A
Completed NCT02957318 - Effect of Potato Fiber on Appetite and Fecal Fat Excretion N/A
Completed NCT04378374 - The Effect of Pulse Flours on Blood Glucose, Satiety and Food Intake N/A
Completed NCT01199770 - Pasta Formulations, Portion Sizes and Their Effect on Appetite N/A
Recruiting NCT05443347 - Activity, Adiposity, and Appetite in Adolescents 2 Intervention N/A
Withdrawn NCT02111486 - Effect of Certain Breakfasts on Appetite Control N/A
Completed NCT02379312 - Comparison of the Satiety Effect of a Very Low Energy Foam With Normal Energy Foams N/A
Completed NCT03701503 - The Comparison of PYY, Ghrelin, GLP1, Glucose Level, Level of Satiety, and Ad Libitum Intake in Obese and Non-Obese Patients After Breakfast With Balanced Macronutrient Composition N/A
Completed NCT01222845 - Glycaemic, Insulinaemic and Appetite Responses to Two Different Types of Porridge N/A
Completed NCT03697486 - The Effect of Breakfast With Different Macronutrient Composition on PYY, Ghrelin, GLP-1,Glucose Level, VAS for Hunger, VAS for Satiety and Ad Libitum Intake 4 Hours After Breakfast in Obese Women N/A
Completed NCT03900130 - The Omnibus Satiety Metric: Predicting Satiety in Humans Through Brain, Blood, and Subjective Data N/A
Completed NCT05012046 - Effect of 100% Orange Juice on Food Intake and Glycemic Response in Adults N/A
Completed NCT02484625 - The Effect of Dairy and Non-Dairy Snacks on Food Intake, Subjective Appetite in Children N/A
Withdrawn NCT01246492 - The Effect of Artificial Sweeteners on Blood Glucose Response N/A
Completed NCT05534152 - Effect of Sumac on Appetite and Food Intake N/A
Completed NCT03974165 - Cereal-based Products Fortified With Legumes and Effects on Glycemic Control and Appetite Regulation N/A
Completed NCT01592149 - Survey of Prevalence of Loss of Appetite in Subject With Health Disorders N/A
Recruiting NCT01121783 - The Effect of Lactisole on the Responses to Glucose Solution N/A
Completed NCT01102907 - Effect of Food Form on Satiety and Gastric Emptying
Completed NCT03128684 - The Effects of Lentil-containing Food Products on Satiety and Food Intake N/A