Covid-19 Clinical Trial
Official title:
Efficacy of Pulmonary Physiotherapy on Hospitalized Patients With Novel Coronavirus 2019 Pneumonia
The aim of this study is to evaluate the efficacy of pulmonary physiotherapy on respiratory functions in hospitalized patients with Novel Coronavirus 2019 pneumonia. Patients will be randomized into 1) intervention group: receiving pulmonary physiotherapy technique to improve pulmonary function and walking training or 2) control group: Usual medical care. Patients in both groups will receive therapeutic incentive spirometer. Various outcome measurements of pulmonary functions will be evaluated before and after of interventions. Mortality rate, hospitalization duration and re-admission will be followed until one month after end of intervention. Also, patient's quality of life will be measured after one month.
In late December 2019, the new coronavirus (COVID-19) emerged in Wuhan, China and it has been
confirmed as the cause of pneumonia in a large number of Chinese patients. The virus, also
known as SARS-CoV-2, has since then spread to more than 200 countries worldwide.
The most common symptoms of COVID-19 are fever, dry cough, shortness of breath and tiredness.
In severe cases, the infection could cause pneumonia, acute respiratory distress syndrome
(ARDS) and sometimes leads to death. Pulmonary physiotherapy is a comprehensive, effective
and safe treatment method which is aimed at improving patient's respiratory symptoms, train
effective coughing, clear the airway secretion, eliminate exacerbation and so on. It seems
that pulmonary physiotherapy interventions can effectively decrease hospitalization, reduce
the risk of complications and improve the patient's medical condition.
The aim of this study is to evaluate the effectiveness of the hold breathing technique, chest
expansion exercise, postural drainage procedure and Cough techniques carried out during
pulmonary physiotherapy sessions.
The researchers will invite 40 hospitalized patients in Imam Khomeini Hospital Complex,
Tehran, Iran. All patients will be enrolled after taking informed consent. All of the
procedure will be performed with the coordination of the patient's physicians. Patients will
be randomized to the intervention or control group. Primary outcome measurements will be
evaluated immediately before and after the interventions (with three days period). Also,
patient's condition (including process of disease progression, mortality, hospital stay
duration and re-admission) will be followed until one month using medical records review and
interviewing with the patient or his/her family. Patient's health related quality of life
will be measured using short form-36 quality of life assessment tool one month after the end
of interventions. Intention-to-treat analysis will be performed in the patients that dropped
out of the study.
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