Autoimmunity Clinical Trial
Official title:
Evaluation of the Influence of Salt Intake on TH17 Interleukin(IL)-17 Producing CD4+ Helper T Cells in Human Subjects
The overall goal of this study is to evaluate the association between sodium and TH17 cells in human subjects. The subjects will have levels of TH-17 and various hormones measured on low salt diet, low salt diet with intravenous normal saline, and high salt diet.
In recent years, dietary sodium intake has dramatically increased and has been shown to play an active role in a number of detrimental diseases including hypertension and cardiovascular complications. Additionally, in the developed world, there has been a steady increase in autoimmune diseases. Type 17 helper T cells (Th17) have been shown to play an active role in the development of autoimmune diseases. Serum glucocorticoid kinase (SGK1) has been shown to influence sodium transport and salt homeostasis in many cell types (Wulf, J. Clin. Invest. 2002; Salker, Nature Med 2011). Prior in vitro and in vivo studies have shown that an increase in salt concentration in the media or dietary salt intake in mice induces SGK1 expression and enhances TH17 cell differentiation and worsens experimental autoimmune encephalomyelitis (EAE), animal model for multiple sclerosis (Kleinewietfeld, Nature 2013; Wu, Nature 2013). The findings in this study can substantially increase the investigators understanding of environmental factors that modulate the development of autoimmunity in humans. In animal models the worsening effects of a high salt diet on EAE are dramatic. To the investigators knowledge, the proposed study will be the first to determine if salt intake has the same adverse impact in humans. If documented, one could envision the development of a novel treatment approach for human autoimmunity via the regulation of salt intake. Thus, the overall goal of this study is to evaluate the association between sodium and TH17 cells in human subjects. In addition to measuring TH17 cells by flow cytometry the investigators will also measure interleukins such as IL-17a, IL-17f, IL-23 that are important in TH17 differentiation and production. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02421276 -
Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome
|
N/A | |
Recruiting |
NCT03370861 -
How Microbes and Metabolism May Predict Skin Cancer Immunotherapy Outcomes
|
||
Recruiting |
NCT06363903 -
ASIA-Mesh: a Pilot Study for Diagnostics and Treatment on ASIA Syndrome Caused by Polypropylene Mesh Implantation
|
||
Recruiting |
NCT04791150 -
Rheumatologic Adverse Events and Cancer Immunotherapy
|
N/A | |
Recruiting |
NCT05894746 -
Gfree - For Improved Blood Sugar and Reduced Inflammation.
|
N/A | |
Completed |
NCT02715323 -
Exploring Immune Cell Signatures in Autoimmunity and Dry Eye Syndrome
|
||
Recruiting |
NCT05928585 -
A Study of Safety and Drug Levels of HIB210 in Healthy Volunteers
|
Phase 1 | |
Completed |
NCT03767712 -
Trauma as a Trigger for Autoimmunity
|
||
Recruiting |
NCT03206099 -
NIAID Centralized Sequencing Protocol
|
||
Completed |
NCT00649246 -
Prospective Assessment in Newborns for Diabetes Autoimmunity
|
||
Recruiting |
NCT04521790 -
Role of Endomyocardial Biopsy and Aetiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management
|
||
Terminated |
NCT01129232 -
Diabetes Virus Detection Project, Intervention With GAD-alum
|
Phase 2 | |
Recruiting |
NCT04119713 -
Autoimmunity After Checkpoint Blockade
|
||
Not yet recruiting |
NCT02912442 -
Thyroid Autoimmunity and Reproductive Failure in Danish Women
|
N/A | |
Terminated |
NCT04859829 -
Autoimmune Gastrointestinal Dysmotility: Symptoms, Pathogenesis and Treatment
|