Clinical Trials Logo

Clinical Trial Summary

The purposes of this study are to test whether GAD vaccination can stop the progression of newly diagnosed type 1 diabetes, to describe the related immunological processes (insulitis) in pancreas and small intestines evolving the mechanism of the effect of GAD vaccination and finally try to detect viruses and virus receptors directly in the insulin producing beta cells of the pancreas in patients with newly diagnosed type-1 diabetes mellitus (T1D).


Clinical Trial Description

The aetiology of type 1 diabetes is unknown. Both genetic and environmental factors seem to be important for the destruction of insulin producing beta cells in the pancreas. Increasing indirect evidences exist that picornaviruses may either directly or indirectly through autoimmune processes destroy beta cells. New sensitive assays have been developed to detect these viruses and to study the immunological processes, especially T-cell function. Microsurgical technology has been refined, now making pancreatic biopsies a safe procedure. This study focuses on advanced in depth studies of immunology and virology in pancreatic tissue and small intestine at an early stage of disease. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01129232
Study type Interventional
Source Oslo University Hospital
Contact
Status Terminated
Phase Phase 2
Start date January 2011
Completion date January 2013

See also
  Status Clinical Trial Phase
Completed NCT02421276 - Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome N/A
Recruiting NCT03370861 - How Microbes and Metabolism May Predict Skin Cancer Immunotherapy Outcomes
Recruiting NCT04791150 - Rheumatologic Adverse Events and Cancer Immunotherapy N/A
Recruiting NCT05894746 - Gfree - For Improved Blood Sugar and Reduced Inflammation. N/A
Recruiting NCT02715323 - Exploring Immune Cell Signatures in Autoimmunity and Dry Eye Syndrome
Terminated NCT02261688 - Salt and TH-17 in Healthy Human Subjects N/A
Recruiting NCT05928585 - A Study of Safety and Drug Levels of HIB210 in Healthy Volunteers Phase 1
Completed NCT03767712 - Trauma as a Trigger for Autoimmunity
Recruiting NCT03206099 - NIAID Centralized Sequencing Protocol
Completed NCT00649246 - Prospective Assessment in Newborns for Diabetes Autoimmunity
Recruiting NCT04521790 - Role of Endomyocardial Biopsy and Aetiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management
Recruiting NCT04119713 - Autoimmunity After Checkpoint Blockade
Not yet recruiting NCT02912442 - Thyroid Autoimmunity and Reproductive Failure in Danish Women N/A
Terminated NCT04859829 - Autoimmune Gastrointestinal Dysmotility: Symptoms, Pathogenesis and Treatment