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Clinical Trial Summary

The purpose of the study is to determine if treatment with amivantamab will be efficacious in patients with recurrent and metastatic adenoid cystic carcinoma.


Clinical Trial Description

ACC is a rare cancer of salivary glands and other glandular tissue. It is slow growing and is usually treated with surgery and radiation. However, this type of cancer tends to have a high rate of recurrence and metastatic spread, which develops over several years. We hypothesize that amivantamab, a bispecific EGFR and MET inhibitor will be efficacious in ACC. Patients will receive amivantamab at 1050mg weekly for the first cycle and biweekly thereafter (1400mg for patients ≥80kg). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05074940
Study type Interventional
Source University of Cincinnati
Contact UCCC Clinical Trials Office
Phone 513-584-7698
Email cancer@uchealth.com
Status Recruiting
Phase Phase 2
Start date August 5, 2022
Completion date August 5, 2028

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