APG-115 in Salivary Gland Cancer Trial

Status Suspended

Clinical Trial Summary

This is a phase I/II trial to evaluate the efficacy of APG-115 +/- Carboplatin for the treatment p53 wild-type malignant salivary gland cancer. Part 1 consisted of 2 arms, arm A (APG-115 monotherapy) and arm B (APG-115 + Carboplatin) and was terminated early. Part 2 is a single arm study (APG-115 monotherapy).

Clinical Trial Description

The current single arm study design was originally part of a study with a parallel arm given combination APG-115 + Carboplatin. In the initial phase of that previous iteration, the combination arm was closed early for issues related to tolerability of the combination therapy. This study will continue as a single arm, monotherapy alone, Phase I/II study as approved by the UM Institutional Review Board as of June 2021. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03781986
Study type	Interventional
Source	University of Michigan Rogel Cancer Center
Contact
Status	Suspended
Phase	Phase 1/Phase 2
Start date	October 28, 2019
Completion date	January 2025

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See also
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