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Rupture clinical trials

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NCT ID: NCT04492059 Withdrawn - Clinical trials for Achilles Tendon Rupture

Use of Blood Flow Restriction Therapy in Perioperative Rehabilitation Following Achilles Tendon Rupture

Start date: September 1, 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to examine the effect of utilizing blood flow restriction (BFR) therapy in the rehabilitation of Achilles tendon rupture (ATR). Muscle atrophy occurs following Achilles tendon rupture, whether managed non operatively or operatively, which has implications on patient outcomes. The goal of physical therapy in the perioperative period is to regain and ultimately return to activity. BFR has been proposed to reduce atrophy and maintain strength, which would theoretically mitigate the deconditioning effects of an injury on surrounding musculature. BFR is proposed to work by restricting arterial inflow leading to an oxygen depleted environment and the ability to induce muscle adaption at lower maximum repetition via reactive hyperemia and induction of growth cytokines, thus leading to muscle hypertrophy. The goal of this investigation is to determine if using BFR as an adjunct in physical therapy following ATR would reduce muscular atrophy and lead to increased and expedited strength gains. Additionally, the investigators would like to determine if BFR accelerates the rehabilitation process and allows patients to perform standard rehabilitative functional tests and return to play sooner. Furthermore, the investigators will investigate patient reported outcomes metrics. The investigators hypothesize that the BFR group will have significantly greater strength gains at all time points in both non operatively and operatively treated ATR. Previous studies have shown that BFR has potential in increasing Achilles tendon stiffness, tendon cross-sectional area, muscle strength and muscle hypertrophy. However, there is a lack of evidence regarding the use of BFR in both the pre and postoperative period specifically relating to ATR. The investigators believe that the use of BFR in the perioperative period surrounding an Achilles tendon rupture and ATR has the potential to significantly decreased muscle atrophy, improve patient satisfaction and lead to earlier return to sport.

NCT ID: NCT04488042 Completed - Obesity, Morbid Clinical Trials

Stapler-less Burst Pressure in a Ex-vivo Human Gastric Tissue

Start date: January 1, 2020
Phase: N/A
Study type: Interventional

Stapler-less laparoscopic sleeve gastrectomy (LSG) is emerging as a new potential affordable cost-effective alternative procedure. However, no pre-clinical data are currently available on human tissue. We aimed to evaluate whether traditionally suturing without the use of surgical stapling may produces a comparable bursting pressure on human gastric tissue.

NCT ID: NCT04478942 Recruiting - Clinical trials for Induction of Labor Affected Fetus / Newborn

PROMMO Trial: Oral Misoprostol vs IV Oxytocin

PROMMO
Start date: October 26, 2020
Phase: Early Phase 1
Study type: Interventional

This is a prospective, randomized trial looking at the ideal method of labor induction for women with prelabor rupture of membranes and an unfavorable cervical Bishop score. The study will compare oral misoprostol and intravenous oxytocin.

NCT ID: NCT04478383 Completed - Clinical trials for Achilles Tendon Rupture

Repair of Achilles Sleeve Avulsion: a New Transosseous Suture Technique

Start date: August 1, 2017
Phase:
Study type: Observational

This retrospective study identified 12 patients with Achilles sleeve avulsion from November 2013 to March 2016, aiming to explore a new transosseous suture technique for the repair of Achilles sleeve avulsion and observe the short-term curative effect.

NCT ID: NCT04473638 Completed - Ankle Fractures Clinical Trials

Deltoid Ligament Arthroscopic Repair in Ankle Fractures: Case Series

Start date: August 1, 2019
Phase:
Study type: Observational

To demonstrate the functional results of patients with ankle fractures operated with arthroscopic deltoid repair.

NCT ID: NCT04471181 Recruiting - Aneurysm, Ruptured Clinical Trials

Greek Study for Endovascular Repair of Ruptured Abdominal Aortic Aneuryms

GRAND
Start date: February 1, 2020
Phase:
Study type: Observational

This will be a non-randomized, prospective, observational multi-center research study. Its purpose will be to assess the mortality and outcome of EVAR in patients with rAAA. As mentioned in the introduction, EVAR approach for ruptured bdominal aortic aneurysms is nowdays common clinical practice in many vascular centers , and the main treatment option in Hippokrateio General hospital. The same applies in all future participating vascular centers.

NCT ID: NCT04465994 Completed - Clinical trials for Acute Rupture of Achilles Tendon (Disorder)

Comparison of Primary Repair Versus Gastrocnemius Turn-down Flaps of Acute Achilles Tendon Rupture

Start date: January 5, 2020
Phase:
Study type: Observational

This retrospective study includes 74 patients with acute Achilles tendon rupture from March 2012 to September 2018, aiming to compare the mid-term curative effect of primary repair and gastrocnemius turn-down flaps and guide clinical decision.

NCT ID: NCT04464343 Completed - Clinical trials for Posterior Cruciate Ligament Tear

The Biomechanical Mechanism for Gait and Plantar Pressure Changes After Posterior Cruciate Ligament Rupture and Reconstruction

Start date: June 14, 2014
Phase:
Study type: Observational

Investigating the biomechanics for the PCL ruptured or reconstructed patients during walking, jogging, cutting, jumping. To establish a knee joint biomechanical evaluation model to quantify and evaluate the plantar pressure information under dynamic load-bearing state after PCL fracture. Provide a precise basis for the biomechanical state of the knee, and establish a clinically practical automatic analysis of plantar pressure information and an expert diagnostic system.

NCT ID: NCT04464330 Active, not recruiting - Clinical trials for Anterior Cruciate Ligament Injuries

Biomechanical Mechanism of the Change of the Gait Touch Information After ACL Rupture

Start date: April 2, 2017
Phase:
Study type: Observational

High incidence rate of knee osteoarthritis and gait analysis are important for early assessment of biomechanics. ACL injury is an ideal clinical model for studying knee osteoarthritis. To clarify the mechanism between the biomechanical status of knee joint and the change of gait touch information, and to provide scientific basis for quantifying and evaluating the biomechanical status of knee joint in dynamic load-bearing state.

NCT ID: NCT04462432 Active, not recruiting - Clinical trials for Anterior Cruciate Ligament Injuries

Spatiotemporal Characteristics and Multi-body Dynamics Modeling Information After ACL Rupture and Reconstruction

Start date: March 2, 2017
Phase:
Study type: Observational

High incidence rate of knee osteoarthritis and gait analysis are important for early assessment of biomechanics. ACL injury is an ideal clinical model for studying knee osteoarthritis. To clarify the mechanism between the biomechanical status of knee joint and the change of gait touch information, and to provide scientific basis for quantifying and evaluating the biomechanical status of knee joint in dynamic load-bearing state.