Rupture of Anterior Cruciate Ligament Clinical Trial
Official title:
A Pilot Study to Investigate Biomarkers in ACL Patients and Healthy Controls
Incident rates of ACL rupture are greatest in 16-39 year olds at almost 1 in 1,000. Performance Based Investigations (PBIs) can be used to evaluate and select correct approaches to patient treatment, and biochemical, biomechanical and physiological biomarkers in other conditions are sensitive in distinguishing between disease state severities, type of injuries and responsiveness to treatment. Despite the measurement sensitivity of PBIs, these are not widely used possibly owing to their focus postoperatively where benefits are less worthwhile. This study aims to investigate novel biomarkers as performance based investigations (PBIs) to improve surgical and treatment strategies in anterior cruciate ligament (ACL) patients. The objectives are to identify whether biomarkers, collected before and after operations, can: 1) Assist the surgeon in decision making; 2) Lead to improved prognosis; 3) Be used to predict the outcomes of prognosis, and; 4) Correlate with disease signs/ smoking to help further understand ACL injuries.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02524652 -
Local Infiltration Analgesia vs Adductor Canal Block for Analgesia After Anterior Cruciate Ligament Reconstruction
|
Phase 4 | |
| Recruiting |
NCT02511158 -
French Prospective Anterior Cruciate Ligament Reconstruction Cohort Study (FAST)
|
||
| Recruiting |
NCT02074917 -
Comparison of Dynamic Knee Stability and Functional Outcomes in Anatomical ACL Reconstruction at AM or Central Position
|
N/A | |
| Completed |
NCT02584452 -
Trial Evaluating Postop Pain and Muscle Strength Among Regional Anesthesia Techniques for Ambulatory ACL Reconstruction
|
N/A | |
| Completed |
NCT01300182 -
The Effect of Early WBVT on Neuromuscular Control After ACLR
|
N/A | |
| Recruiting |
NCT00971451 -
Quadriceps Function Prior to Anterior Cruciate Ligament Reconstruction
|
N/A | |
| Completed |
NCT02420353 -
Evaluation of rGH Therapy to Prevent Muscle Atrophy in Patients With ACL Tears
|
Phase 2 | |
| Completed |
NCT02173483 -
Anterior Cruciate Ligament-reconstruction: Quadriceps Tendon or Hamstrings Tendon? A Prospective Trial
|
N/A | |
| Completed |
NCT02754674 -
Comparison of Femoral Tunnel and Clinical Outcome Using Two Anterior Cruciate Ligament Reconstruction Techniques
|
N/A | |
| Completed |
NCT01440348 -
Simultaneous Multiple Cruciate Ligament Reconstructions Using a Single Achilles Allograft
|
Phase 4 | |
| Completed |
NCT01391650 -
Stability of the Knee Joint After Single and Double Bundle Anterior Cruciate Ligament Reconstruction
|
N/A | |
| Not yet recruiting |
NCT02833454 -
Study of the Anatomical Direct Insertion Anterior Cruciate Ligament Reconstruction
|
N/A | |
| Not yet recruiting |
NCT02834962 -
Study of Single And Double Bundle Anterior Cruciate Ligament (ACL) Graft Cross-sectional Dimensions
|
N/A | |
| Completed |
NCT02939677 -
Can Targeted Exercise Improve Knee Strength Following ACLR (RATE)
|
N/A | |
| Completed |
NCT02817399 -
The Effect of Functional Electrical Stimulation
|
N/A | |
| Recruiting |
NCT02771548 -
Biomechanical Analysis of Dynamic Tasks and Muscular Strength Following Anterior Cruciate Ligament Reconstruction
|
||
| Completed |
NCT01361789 -
COX-2 Inhibitor Versus Glucocorticoid Versus Both Combined
|
Phase 4 | |
| Completed |
NCT00463099 -
Multicenter Orthopaedics Outcomes Network for ACL Reconstructions
|
||
| Active, not recruiting |
NCT02680821 -
Reconstruction of the Anterolateral Ligament (ALL) With Revision Anterior Cruciate Ligament (ACL) Surgery
|
N/A | |
| Active, not recruiting |
NCT00625885 -
Multicenter ACL Revision Study (MARS)
|