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Right Ventricular Pacing clinical trials

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NCT ID: NCT06241651 Recruiting - Heart Failure Clinical Trials

CSP Versus BiVP for Heart Failure Patients With RVP Upgraded to Cardiac Resynchronization Therapy

CSP-UPGRADE
Start date: January 1, 2024
Phase: N/A
Study type: Interventional

The present study is a prospective, multicenter, non-inferiority, randomized controlled trail. It aims to investigate whether the efficacy of conduction system pacing (CSP) is non-inferior to biventricular pacing (BiVP) in patients with heart failure and right ventricular pacing (RVP) requiring upgrading to cardiac resynchronization therapy (CRT).

NCT ID: NCT06197503 Recruiting - Clinical trials for Transcatheter Aortic Valve Implantation

Randomized Study of Physiological vs Right Ventricular Pacing in Patients With Normal Ventricular Function Post TAVI

PHYSTAVIII
Start date: November 30, 2023
Phase: N/A
Study type: Interventional

Single-center randomized trial in patients with pacing indication (AV block) after TAVI (transfemoral aortic valve implantation) and LVEF> 50%, that aims to study the percentage of patients who improve at 12 months in a combined clinical endpoint.

NCT ID: NCT06023784 Not yet recruiting - Atrial Fibrillation Clinical Trials

The Impact of LBBAP vs RVP on the Incidence of New-onset Atrial Fibrillation in Patients With Atrioventricular Block

Start date: September 30, 2023
Phase: N/A
Study type: Interventional

This is a single-center, randomized controlled study. The aim of this study is to compare the impact of left bundle branch area pacing versus traditional right ventricular pacing on the incidence of atrial fibrillation in patients with atrioventricular block.

NCT ID: NCT05815745 Recruiting - Bradycardia Clinical Trials

"Physiological vs Right Ventricular Pacing Outcome Trial Evaluated for bradyCardia Treatment" (PROTECT-HF)

PROTECT-HF
Start date: June 5, 2023
Phase: N/A
Study type: Interventional

The PROTECT-HF multi-centre randomised controlled trial will compare two different pacing approaches for treating patients with slow heart rates. In it the investigators will compare a long-standing standard approach for pacing; right ventricular pacing, with a new form of pacing, physiological pacing (His and Left bundle area pacing) in 2600 patients. Patients will be allocated at random to receive either right ventricular pacing or physiological pacing. Endpoint measurements will be undertaken at baseline, and at six-monthly intervals post-randomisation. Treatment allocation will be blinded to the endpoint assessor and the patient. Recruitment and pacemaker implantation will be carried out at each participating centre. The primary analysis will be intention to treat. The investigators will also perform an on-treatment analysis. 2048 patients are needed to detect the expected effect size with 85% power. A total of 2600 patients will be recruited to allow for patient drop-out and crossover. 500-patient sub-study will assess within patient, and between groups, echocardiographic changes over a 24-month period to try and improve mechanistic understanding of PICM (Pacing Induced Cardiomyopathy).

NCT ID: NCT05222672 Completed - Pacemaker DDD Clinical Trials

Electrical and Mechanical Activation in PAcing The His Bundle Conduction sYstem

EMPATHY
Start date: February 1, 2021
Phase:
Study type: Observational

In recent years, the finding of long-term deleterious effects of right ventricular pacing (RVP) has led to an ongoing search for alternative pacing sites such as His bundle stimulation. The depolarization of the ventricles through the His-Purkinje cardiac conduction system seems to represent an ideal physiological approach to ventricular pacing, capable of engaging the normal conduction pathways and determining synchronous ventricular activation. However, there are still no clinical studies that have evaluated the electromechanical functions of the left ventricle with His bundle pacing (HBP) identified after electroanatomical reconstruction with 3D mapping system. Investigators aimed to compare the electromechanical effects on left ventricle of HBP, compared to RVP stimulation and to spontaneous rhythm of each patient.

NCT ID: NCT04730921 Recruiting - Heart Failure Clinical Trials

Impact of Left Bundle Branch Area Pacing vs. Right Ventricular Pacing in Atrioventricular Block (LEAP-Block)

LEAP-Block
Start date: November 13, 2020
Phase: N/A
Study type: Interventional

This is a multicenter, randomized controlled study. The aim of this study is to compare the impact of LBBAP on left ventricular function as compared with traditional right ventricular pacing in patients with atrioventricular block.

NCT ID: NCT04482816 Completed - Clinical trials for Transcatheter Aortic Valve Implantation

Physiological vs Right Ventricular Pacing in Patients With Normal Ventricular Function Post-TAVI

PHYS-TAVI
Start date: September 14, 2020
Phase: N/A
Study type: Interventional

Single-center randomized trial in patients with pacing indication (AV block) after TAVI (transfemoral aortic valve implantation) and LVEF> 50%, that aims to study the percentage of patients who improve at 12 months in a combined clinical endpoint.

NCT ID: NCT00949715 Completed - Cardiac Pacing Clinical Trials

Optimize RV Follow-up Selective Site Pacing Clinical Trial

ORVFUP
Start date: September 2009
Phase: N/A
Study type: Interventional

The purpose of the Optimize RV Follow-Up study is to determine the long-term effect of selective site pacing. Selective site pacing refers to which area of the right ventricle the lead is placed. The goal of selective site pacing is to improve how the heart contracts when paced.